215430

α-(4-Pyridyl N-oxide)-N-tert-butylnitrone

99%

• Szinonimák: N-(4-Pyridylmethylene)-tert-butylamine N,N′-dioxide, N-tert-Butyl-α-(4-pyridyl)nitrone N′-oxide, POBN
• Tapasztalati képlet (Hill-képlet): C₁₀H₁₄N₂O₂
• CAS-szám: 66893-81-0
• Molekulatömeg: 194.23
• Beilstein: 1453764
• EC-szám: 266-512-3
• MDL-szám: MFCD00041022
• UNSPSC kód: 12352100
• PubChem Substance ID: 24852894
• NACRES: NA.22
• Forma: solid
• Teszt: 99%

Tulajdonságok

• Teszt: 99%
• Forma: solid
• mp: 183-185 °C (lit.)
• oldhatóság: water: soluble 10 mg/mL, clear, colorless to faintly yellow
• funkcionális csoport: amine
• SMILES string: CC(C)(C)\[N+]([O-])=C/c1cc[n+]([O-])cc1
• InChI: 1S/C10H14N2O2/c1-10(2,3)12(14)8-9-4-6-11(13)7-5-9/h4-8H,1-3H3/b12-8+
• Nemzetközi kémiai azonosító kulcs: RNRMWTCECDHNQU-XYOKQWHBSA-N

Leírás

Alkalmazás

α-(4-Pyridyl N-oxide)-N-tert-butylnitrone was used as spin trapping agent to detect:

• the formation of hydroxyl radical adducts during decomposition of hydrogen peroxide in the presence of nickel (II) oligopeptides
• hydroxyl radicals and selenide radical anions

Spin trap reagent used to measure ethanol oxidation to 1-hydroxyethyl radical (HER) which can bind to protein. Has also been used in studies of DNA methylation, iron-mediated polyunsaturated fatty acid peroxidation, and free-radical formation by Alzheimer β-amyloid peptide. The formation of hydroxyl radical in chondrocytes and cartilage has been detected using POBN.

Biztonsági adatok

• Tárolási osztály kódja: 11 - Combustible Solids
• WGK: WGK 3
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable
• Egyéni védőeszköz: Eyeshields, Gloves, type N95 (US)