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T5428

Sigma-Aldrich

Tetramethylrhodamine methyl ester perchlorate

≥95% purity, powder

Sinônimo(s):

TMRM

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About This Item

Fórmula linear:
C25H25N2O3 · ClO4
Número CAS:
115532-50-8
Peso molecular:
500.93
Beilstein:
7162165
Número MDL:
MFCD00274460
Código UNSPSC:
12171500
ID de substância PubChem:
24900280
NACRES:
NA.47

product name

Tetramethylrhodamine methyl ester perchlorate, ≥95%

Nível de qualidade

200

Ensaio

≥95%

forma

powder

composição

Carbon: 57.5-62.4%

Nitrogen: 5.3-5.9%

cor

dark green

solubilidade

methanol: 5 mg/mL, clear

εmax

>95000 at 546-552 nm in methanol

fluorescência

λem 573 nm in methanol

aplicação(ões)

diagnostic assay manufacturing
hematology
histology

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

[O-]Cl(=O)(=O)=O.COC(=O)c1ccccc1C2=C3C=C\C(C=C3Oc4cc(ccc24)N(C)C)=[N+](\C)C

InChI

1S/C25H25N2O3.ClHO4/c1-26(2)16-10-12-20-22(14-16)30-23-15-17(27(3)4)11-13-21(23)24(20)18-8-6-7-9-19(18)25(28)29-5;2-1(3,4)5/h6-15H,1-5H3;(H,2,3,4,5)/q+1;/p-1

chave InChI

PFYWPQMAWCYNGW-UHFFFAOYSA-M

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Descrição geral

Tetramethylrhodamine methyl ester perchlorate (TMRM) is a membrane-permeant, cationic, fluorescent dye that can label mitochondria and mark embryonic stem cell/induced pluripotent stem cell-derived cardiomyocytes. It is useful for the isolation of mature cardiomyocytes.

Aplicação

Tetramethylrhodamine methyl ester perchlorate (TMRM) has been used as a sensitive probe for the detection of mitochondrial membrane potential.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Gloves

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Certificados de análise (COA)

Lot/Batch Number
MKCS8855
MKCR6918
MKCQ5317
MKCP9153
MKCM9935

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Therapeutic Targeting of the Mitochondria Initiates Excessive Superoxide Production and Mitochondrial Depolarization Causing Decreased mtDNA Integrity
Kaytee L
PLoS ONE (2016)
Markus Hartl et al.
Molecular systems biology, 13(10), 949-949 (2017-10-25)
Histone deacetylases have central functions in regulating stress defenses and development in plants. However, the knowledge about the deacetylase functions is largely limited to histones, although these enzymes were found in diverse subcellular compartments. In this study, we determined the
Emerging Trends in Cell and Gene Therapy null
Quantitative analysis of mitochondrial morphology and membrane potential in living cells using high-content imaging, machine learning, and morphological binning
Anthony P
Biochimica et Biophysica Acta (2015)
Antigoni Diokmetzidou et al.
Journal of cell science, 129(20), 3705-3720 (2016-08-28)
The association of desmin with the α-crystallin Β-chain (αΒ-crystallin; encoded by CRYAB), and the fact that mutations in either one of them leads to heart failure in humans and mice, suggests a potential compensatory interplay between the two in cardioprotection.
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