SBR00014

Daptomycin Ready Made Solution

1 mg/mL in DMSO

• Synonim(y): N-decanoyl-L-tryptophyl-L-asparaginyl-L-aspartyl-L-threonylglycyl-L-ornithyl-L-aspartyl-D-alanyl-L-aspartylglycyl-D-seryl-threo-3-methyl-L-glutamyl-3-anthraniloyl-L-alanine[egr]₁-lactone
• Wzór empiryczny (zapis Hilla): C₇₂H₁₀₁N₁₇O₂₆
• Numer CAS: 103060-53-3
• Masa cząsteczkowa: 1620.67
• Numer MDL: MFCD28968054
• Kod UNSPSC: 51102829
• NACRES: NA.76

Właściwości

• pochodzenie biologiczne: Streptomyces roseosporus
• Poziom jakości: 200
• opis: Ready Made Solution
• Postać: liquid
• warunki przechowywania: (Keep container tightly closed in a dry and well-ventilated place.)
• stężenie: 1 mg/mL in DMSO
• kolor: colorless to faint yellow
• spektrum działania antybiotyku: Gram-positive bacteria
• Tryb działania: DNA synthesis | interferes; protein synthesis | interferes
• Warunki transportu: dry ice
• temp. przechowywania: −20°C
• ciąg SMILES: O=C(NCC(N[C@H](CCCN)C(N[C@@H](CC(O)=O)C(N[C@H](C)C(N[C@@H](CC(O)=O)C(NC1)=O)=O)=O)=O)=O)[C@@H](NC([C@H](CC(O)=O)NC([C@@H](CC(N)=O)NC([C@H](CC2=CNC3=C2C=CC=C3)NC(CCCCCCCCC)=O)=O)=O)=O)[C@@H](C)OC([C@H](CC(C4=C(N)C=CC=C4)=O)NC([C@@]([C@H](C)CC(O)=O)([H])NC(
• InChI: 1S/C72H101N17O26/c1-5-6-7-8-9-10-11-22-53(93)81-44(25-38-31-76-42-20-15-13-17-39(38)42)66(108)84-45(27-52(75)92)67(109)86-48(30-59(102)103)68(110)89-61-37(4)115-72(114)49(26-51(91)40-18-12-14-19-41(40)74)87-71(113)60(35(2)24-56(96)97)88-69(111)50(34-90)82-55(95)32-77-63(105)46(28-57(98)99)83-62(104)36(3)79-65(107)47(29-58(100)101)85-64(106)43(21-16-23-73)80-54(94)33-78-70(61)112/h12-15,17-20,31,35-37,43-50,60-61,76,90H,5-11,16,21-30,32-34,73-74H2,1-4H3,(H2,75,92)(H,77,105)(H,78,112)(H,79,107)(H,80,94)(H,81,93)(H,82,95)(H,83,104)(H,84,108)(H,85,106)(H,86,109)(H,87,113)(H,88,111)(H,89,110)(H,96,97)(H,98,99)(H,100,101)(H,102,103)/t35?,36-,37?,43+,44+,45+,46+,47+,48+,49+,50-,60+,61?/m1/s1
• Klucz InChI: DOAKLVKFURWEDJ-OFNKPWESSA-N

Opis

Działania biochem./fizjol.

Daptomycin is a natural cyclic lipopeptide antibiotic found in Streptomyces roseosporus. It is has been found to be effective in treating infections caused by aerobic Gram-positive bacteria. Daptomycin inhibits many antibiotic resistant strains such as methicillin-resistant S. aureus (MRSA), vancomycin-intermediate S. aureus (VISA) and vancomycin-resistant S. aureus (VRSA).

The mode of action of daptomycin is quite different from that of any other antibiotic. Daptomycin binds to bacterial membranes and causes a rapid depolarization of membrane potential. This loss of membrane potential causes inhibition of protein, DNA, and RNA synthesis, which results in bacterial cell death.

Opakowanie

0.5ML

Uwaga dotycząca przygotowania

The 1 mg/mL solution may be further diluted in an appropriate buffer prior to use. It is recommended that a fresh dilution be made on the day of use.

Inne uwagi

Keep container tightly closed in a dry and well-ventilated place.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 10 - Combustible liquids
• Klasa zagrożenia wodnego (WGK): WGK 1
• Temperatura zapłonu (°F): 188.6 °F
• Temperatura zapłonu (°C): 87 °C