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Merck

K8625

Sigma-Aldrich

L-Kynurenine

≥98% (HPLC)

Synonim(y):

β-Anthraniloyl-L-alanine, L-2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid

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25 MG
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100 MG
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500 MG
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25 MG
309,00 zł
100 MG
1000,00 zł
500 MG
2930,00 zł
1 G
5050,00 zł

About This Item

Wzór empiryczny (zapis Hilla):
C10H12N2O3
Numer CAS:
Masa cząsteczkowa:
208.21
Numer MDL:
Kod UNSPSC:
12352209
Identyfikator substancji w PubChem:
NACRES:
NA.26

309,00 zł


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Nazwa produktu

L-Kynurenine, ≥98% (HPLC)

Próba

≥98% (HPLC)

Formularz

powder

mp

219 °C

Zastosowanie

detection

ciąg SMILES

N[C@@H](CC(=O)c1ccccc1N)C(O)=O

InChI

1S/C10H12N2O3/c11-7-4-2-1-3-6(7)9(13)5-8(12)10(14)15/h1-4,8H,5,11-12H2,(H,14,15)/t8-/m0/s1

Klucz InChI

YGPSJZOEDVAXAB-QMMMGPOBSA-N

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Zastosowanie

L-Kynurenine has been used as a standard for indoleamine-2,3-dioxygenase (IDO) assay.[1] It has also been used as a standard to extract and quantify kynurenine from cultured cells and media.[2]

Działania biochem./fizjol.

Key intermediate in the breakdown pathway of tryptophan.
L-Kynurenine is a key intermediate in the breakdown of L-tryptophan[3] and the formation of nicotinamide adenine dinucleotide (NAD+) via the kynurenine pathway. It is involved in a variety of neurological processes and diseases.[4][5] L-Kynurenine is a substrate for kynureninase/kynurenine hydrolase; kynurenine 3-monooxygenase and kynurenine-oxoglutarate transaminase.
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Kod klasy składowania

11 - Combustible Solids

Klasa zagrożenia wodnego (WGK)

WGK 3

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

Środki ochrony indywidualnej

Eyeshields, Gloves, type N95 (US)


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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Evaluation of radiofluorinated carboximidamides as potential IDO-targeted PET tracers for cancer imaging
Xuan Huang
Oncotarget, 8(29), 46900-46914 (2017)
Extraction and Quantification of Tryptophan and Kynurenine from Cultured Cells and Media Using a High Performance Liquid Chromatography (HPLC) System Equipped with an Ultra-Sensitive Diode Array Detector
Jeffrey Kim
Bio-protocol, 6(7), e1781-e1781 (2016)
Kynurenine Pathway Metabolites in Humans: Disease and Healthy States
Yiquan Chen
International Journal of Tryptophan Research : IJTR, 2, 1-19 (2009)
The Involvement of Neuroinflammation and Kynurenine Pathway in Parkinson's Disease
Anna Zinger
Parkinson's Disease (2011)
Essential and Non-Essential Metals Metabolites with Antibiotic Activity Pharmacology of Benzodiazepines Interferon Gamma Research (2012)

Questions

1–3 of 3 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  3. Ist gelöstes Kynurenine bei -20°C haltbar und wenn ja wie lang?

    1 answer
    1. The stability of the solution at -20 °C is not determined. Upon resuspension of L-Kynurenine, it is recommended to store solutions at 15-25 °C. The resuspended product is stable for 6 months when properly stored. It is also recommended to protect this product from light.

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