G6649

Genistein

≥98% (HPLC), powder, tyrosine protein kinase inhibitor

• Synonim(y): 4′,5,7-Trihydroxyisoflavone, 5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
• Wzór empiryczny (zapis Hilla): C₁₅H₁₀O₅
• Numer CAS: 446-72-0
• Masa cząsteczkowa: 270.24
• Beilstein: 263823
• Numer WE: 207-174-9
• Numer MDL: MFCD00016952
• Kod UNSPSC: 12352200
• Identyfikator substancji w PubChem: 24278036
• NACRES: NA.77

Właściwości

• Nazwa produktu: Genistein, synthetic, ≥98% (HPLC), powder
• pochodzenie biologiczne: synthetic
• Poziom jakości: 200
• Próba: ≥98% (HPLC)
• Formularz: powder
• kolor: off-white to yellow
• mp: 297.0-298.0 °C
• rozpuszczalność: DMSO: soluble; ethanol: soluble
• temp. przechowywania: −20°C
• ciąg SMILES: Oc1ccc(cc1)C2=COc3cc(O)cc(O)c3C2=O
• InChI: 1S/C15H10O5/c16-9-3-1-8(2-4-9)11-7-20-13-6-10(17)5-12(18)14(13)15(11)19/h1-7,16-18H
• Klucz InChI: TZBJGXHYKVUXJN-UHFFFAOYSA-N
• informacje o genach: human ... AKT1(207) , CYP19A1(1588) , EGFR(1956) , ESR1(2099) , ESR2(2100) ; mouse ... Esr1(13982) , Hexa(15211) ; rat ... Adora1(29290) , Adora2a(25369) , Ar(24208)

Opis

Opis ogólny

Genistein is an isoflavonoid present among Leguminosae family of plants. It is structurally similar to estrogen (estradiol-17β).[1]

Zastosowanie

Genistein has been used:

• as a test compound to access its estrogeniic acivity[2]
• as an oestrogenic ligand to carry out identical reporter gene activation assays and also used to examine the binding of genistein to hERβ[3]
• as an endocytosis inhibitor to test the possible effect of endocytosed advanced glycation end - bovine serum albumin (AGE-BSA) on lysosomes[4]

Działania biochem./fizjol.

Genistein is essential for plant-microbe interaction. It acts as a natural chemoprotectant and helps in preventing tumor progression and heart disorders. Genistein functionally shares estrogen′s action. It is useful in evaluating nutraceuticals and functional foods. Genistein exhibits antimicrobial action and can serve as a phytoalexin and phytoanticipin.[1]

Inhibitor of tyrosine protein kinase; competitive inhibitor of ATP in other protein kinase reactions. Antiangiogenic agent, down-regulates the transcription of genes involved in controlling angiogenesis.

Cechy i korzyści

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Chloride Channels and Met pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Uwaga dotycząca przygotowania

Genistein is soluble in DMSO and ethanol. It is also soluble in chlorform:methanol (1:1 (v:v), 10 mg/ml).

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS07
• Hasło ostrzegawcze: Warning
• Zwroty wskazujące rodzaj zagrożenia: H302
• Zwroty wskazujące środki ostrożności: P264 - P270 - P301 + P312 - P501
• Klasyfikacja zagrożeń: Acute Tox. 4 Oral
• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• Środki ochrony indywidualnej: Eyeshields, Faceshields, Gloves, type N95 (US)