B7510

Beauvericin

≥97% (HPLC), suitable for HPLC

• Synonim(y): cyclo(D-α-Hydroxyisovaleryl-L-N-methyl-Phe)₃
• Wzór empiryczny (zapis Hilla): C₄₅H₅₇N₃O₉
• Numer CAS: 26048-05-5
• Masa cząsteczkowa: 783.95
• UNSPSC Code: 12352209
• PubChem Substance ID: 24891996
• NACRES: NA.26
• MDL number: MFCD00056846

Właściwości

• Nazwa produktu: Beauvericin, ≥97% (HPLC)
• Quality Segment: 200
• assay: ≥97% (HPLC)
• form: powder or crystals
• technique(s): HPLC: suitable
• color: white to off-white
• storage temp.: 2-8°C
• SMILES string: CC(C)C1OC(=O)C(Cc2ccccc2)N(C)C(=O)C(OC(=O)C(Cc3ccccc3)N(C)C(=O)C(OC(=O)C(Cc4ccccc4)N(C)C1=O)C(C)C)C(C)C
• InChI: 1S/C45H57N3O9/c1-28(2)37-40(49)46(7)35(26-32-21-15-11-16-22-32)44(53)56-39(30(5)6)42(51)48(9)36(27-33-23-17-12-18-24-33)45(54)57-38(29(3)4)41(50)47(8)34(43(52)55-37)25-31-19-13-10-14-20-31/h10-24,28-30,34-39H,25-27H2,1-9H3
• InChI key: GYSCAQFHASJXRS-UHFFFAOYSA-N

Opis

General description

Beauvericin is a cyclohexadepsipeptide from the fungus Beauveria bassiana that belongs to the enniatin antibiotic family.[1] It comprises three D-hydroxyisovaleryl and N-methylphenylalanyl residues each.[1]

Application

Beauvericin has been used as an antimicrobial bioactive compound to test its effect on engineered Saccharomyces cerevisiae strains.[2] It has also been used as a mycotoxin standard in the reverse-phase (RP) high-pressure liquid chromatography (HPLC) to quantify mycotoxins produced by Fusarium oxysporum isolates.[3]

Biochem/physiol Actions

Beauvericin (BEA) is a commercial entomopathogenic mycoinsecticide with antiviral, antibacterial, insecticidal, and cytotoxic properties.[1] It elicits apoptotic and nematicidal activities as well.[4] Beauvericin blocks multidrug efflux and Tor complex 1 (TORC1) kinase.[5] It possesses ionophoric functionality and favors channel formation in patches of ventricular myocytes and synthetic membranes.[6] It is shown to inhibit L-type voltage-dependent Ca²⁺ current in the neuroblastoma cells.[7]

Beauvericin (BEA), a cyclohexadepsipeptide produced by the fungus Beauveria bassiana (Bals.), has antiviral, antibacterial, nematicidal, insecticidal, cytotoxic, and apoptotic activity.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)