The analytical standard version of this compound, 34037, is a 10ug/mL solution in acetonitrile. This product is also soluble in chloroform (9.80 - 10.20 mg/ml), methanol (10 mg/ml), ethanol (50 mM), and DMSO (100 mM). The choice of solvent would be best determined by the researcher.
O1877
Ochratoxin A
from Petromyces albertensis, ≥98% (HPLC), powder, mycotoxin
Ochratoxin A
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Synonim(y):
N-[(3R)-(5-Chloro-8-hydroxy-3-methyl-1-oxo-7-isochromanyl)carbonyl]-L-phenylalanine
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Wybierz wielkość
1 MG
813,00 zł
5 MG
2670,00 zł
25 MG
9150,00 zł
813,00 zł
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Informacje o tej pozycji
Wzór empiryczny (zapis Hilla):
C20H18ClNO6
Numer CAS:
Masa cząsteczkowa:
403.81
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Beilstein/REAXYS Number:
1301486
Przejdź do
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Pozwól nam pomócNazwa produktu
Ochratoxin A, from Petromyces albertensis, ≥98% (HPLC)
biological source
Petromyces albertensis
Quality Level
assay
≥98% (HPLC)
form
powder
impurities
Benzene, free
solubility
ethanol: soluble
mode of action
enzyme | inhibits, protein synthesis | interferes
storage temp.
2-8°C
SMILES string
C[C@@H]1Cc2c(Cl)cc(c(O)c2C(=O)O1)C(=O)N[C@@H](Cc3ccccc3)C(O)=O
InChI
1S/C20H18ClNO6/c1-10-7-12-14(21)9-13(17(23)16(12)20(27)28-10)18(24)22-15(19(25)26)8-11-5-3-2-4-6-11/h2-6,9-10,15,23H,7-8H2,1H3,(H,22,24)(H,25,26)/t10-,15+/m1/s1
InChI key
RWQKHEORZBHNRI-BMIGLBTASA-N
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Ta pozycja | |||
|---|---|---|---|
| form powder | form powder | form - | form - |
| assay ≥98% (HPLC) | assay ≥97% (HPLC) | assay - | assay - |
| Quality Level 300 | Quality Level 100 | Quality Level 100 | Quality Level 300 |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. −20°C | storage temp. -10 to -25°C |
| solubility ethanol: soluble | solubility DMSO: 50 mg/mL, nearly colorless | solubility methanol: soluble 5 mg/mL, clear, yellow(lit.) | solubility - |
| biological source Petromyces albertensis | biological source - | biological source - | biological source - |
Application
Ochratoxin A has been used as a mycotoxin:
- to test its effect on metabolism and hypoxia in human embryonic kidney (HEK293) cells[1]
- to test its cytotoxic effects in bovine mammary epithelial cells[2]
- as a standard for gamma radiation studies with food products and in cytotoxic studies using Hep G2 cells[3]
Biochem/physiol Actions
Ochratoxin A (OTA), a renal toxin, is produced majorly by Aspergillus and Penicillium fungal species.[1] It is immunotoxic, teratogenic[2] myelotoxic, and mutagenic.[3] It effectively interrupts the intestinal barrier functions.[2] OTA displays a long elimination half-life[3] and stimulates the major inflammatory cytokines release.[2]
Ochratoxin A is a mycotoxin found in food that is nephrotoxic and carcinogenic in the kidney and induces differentiation in cloned renal cell lines. Increases endoplasmic reticulum ATP-dependent Ca2+ pump activity.
Preparation Note
This product is also soluble in chloroform (9.80 - 10.20 mg/ml), methanol (10 mg/ml), ethanol (50 mM), and DMSO (100 mM).
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signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 2 Oral - Carc. 2
Klasa składowania
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
A Dörrenhaus et al.
Archives of toxicology, 71(11), 709-713 (1997-01-01)
In cultured rat hepatocytes the mycotoxin ochratoxin A (OTA) induced unscheduled DNA synthesis (UDS) only in a narrow concentration range. Using a culture medium supplemented with 1% fetal calf serum, at 750 nM OTA a weak induction and at 1
I Baudrimont et al.
Toxicology, 89(2), 101-111 (1994-04-18)
Ochratoxin A (OTA) is a mycotoxin produced by Aspergillus ochraceus as well as other molds. It is a natural contaminant of mouldy food and feed. OTA has a number of toxic effects, the most prominent being nephrotoxicity. Furthermore, OTA is
C E Groves et al.
Journal of the American Society of Nephrology : JASN, 10(1), 13-20 (1999-01-16)
Primary cultures of rabbit renal proximal tubule cells grown under improved culture conditions were used to study the transepithelial transport of the nephrotoxic mycotoxin ochratoxin A. The basal-to-apical transepithelial flux, i.e., secretion, of this fluorescence organic acid was measured in
G Dirheimer et al.
IARC scientific publications, 115(115), 171-186 (1991-01-01)
Ochratoxin A has a number of toxic effects in mammals, the most notable of which is nephrotoxicity. It is also immunosuppressive, teratogenic and carcinogenic. The biochemical and molecular aspects of its action were first studied in bacteria. The appearance of
X Chong et al.
Biochemical pharmacology, 44(7), 1401-1409 (1992-10-06)
A disruption of calcium homeostasis, leading to a sustained increase in cytosolic calcium levels, has been associated with cytotoxicity in response to a variety of agents in different cell types. We have observed that administration of a single high dose
Produkty
DNA damage and repair mechanism is vital for maintaining DNA integrity. Damage to cellular DNA is involved in mutagenesis, the development of cancer among others.
Numer pozycji handlu globalnego
| SKU | NUMER GTIN |
|---|---|
| O1877-25MG | 04061833273272 |
| O1877-1MG | 04061838446435 |
| O1877-5MG | 04061838446442 |
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Which solvents can be used for an OTA standard solution? PBS, alcoholic solvents (methanol or ethanol)?
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