46401

Cycloheximide

PESTANAL^®, analytical standard

• Synonim(y): 3-[2-(3,5-Dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]glutarimide, Actidione, Naramycin A
• Wzór empiryczny (zapis Hilla): C₁₅H₂₃NO₄
• Numer CAS: 66-81-9
• Masa cząsteczkowa: 281.35
• Beilstein: 88868
• Numer WE: 200-636-0
• Numer MDL: MFCD00082346
• Kod UNSPSC: 41116107
• Identyfikator substancji w PubChem: 329757163
• NACRES: NA.24

Właściwości

• klasa czystości: analytical standard
• Poziom jakości: 100
• opis: mixture of stereo isomers
• linia produktu: PESTANAL^®
• Próba: ≥95% (HPLC)
• okres trwałości: limited shelf life, expiry date on the label
• metody: HPLC: suitable; gas chromatography (GC): suitable
• rozpuszczalność: H₂O: slightly soluble
• spektrum działania antybiotyku: fungi
• Zastosowanie: agriculture; cleaning products; cosmetics; environmental; food and beverages; personal care
• format: neat
• Tryb działania: protein synthesis | interferes
• temp. przechowywania: −20°C
• ciąg SMILES: [H][C@]1(C[C@@H](C)C[C@H](C)C1=O)[C@H](O)CC2CC(=O)NC(=O)C2
• InChI: 1S/C15H23NO4/c1-8-3-9(2)15(20)11(4-8)12(17)5-10-6-13(18)16-14(19)7-10/h8-12,17H,3-7H2,1-2H3,(H,16,18,19)/t8-,9-,11-,12+/m0/s1
• Klucz InChI: YPHMISFOHDHNIV-FSZOTQKASA-N

Opis

Opis ogólny

Cycloheximide is an antibiotic having significant antifungal properties. It is produced by streptomycin-producing strains of Streptomyces griseus and acts by inhibiting protein synthesis. Its main biological activity is translation inhibition in eukaryotes resulting in cell growth arrest and cell death. It is used as a fungicide.
As per Regulation (EC) No 1107/2009, repealing the directive 91/414, cycloheximide is not approved for use in the European Union (EU).

Zastosowanie

Cycloheximide may find the following uses:

• To evaluate the antifungal efficacy and safety of cycloheximide as a supplement in Optisol-GS
• To study the effect of cycloheximide on leaf-cutting ant workers
• To study the effect of streptomycin, cycloheximide, fungizone, captan, carbofuran, cygon, and pentachloronitrobenzene on soil microorganisms
• To study the fungal control of nitrous oxide production in a semiarid grassland
• To study the activity and degradation of streptomycin and cycloheximide in soil

Działania biochem./fizjol.

Mode of Action: Translation inhibition in eukaryotes resulting in cell growth arrest and cell death. CHX is widely used for the selection of CHX-resistant strains of yeast and fungi, controlled inhibition of protein synthesis for detection of short-lived proteins and super-induction of protein expression, and apoptosis induction or facilitation of apoptosis induction by death receptors.

Activity Spectrum: Active against yeast and fungi like Candida, Aspergillus, Saccharomyces, Penicillium

Informacje prawne

PESTANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS06,GHS08,GHS09
• Hasło ostrzegawcze: Danger
• Zwroty wskazujące rodzaj zagrożenia: H300,H341,H360D,H411
• Zwroty wskazujące środki ostrożności: P202 - P264 - P273 - P280 - P301 + P310 - P391
• Klasyfikacja zagrożeń: Acute Tox. 2 Oral - Aquatic Chronic 2 - Muta. 2 - Repr. 1B
• Kod klasy składowania: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• Środki ochrony indywidualnej: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges