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Merck

216143

Sigma-Aldrich

Tetrabutylammonium fluoride solution

1.0 M in THF

Synonim(y):

TBAF solution

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5 ML
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50 ML
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100 ML
571,00 zł
4 X 100 ML
1530,00 zł
500 ML
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1 L
2660,00 zł
2.5 L
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188,00 zł


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5 ML
188,00 zł
50 ML
327,00 zł
100 ML
571,00 zł
4 X 100 ML
1530,00 zł
500 ML
2180,00 zł
1 L
2660,00 zł
2.5 L
5710,00 zł

About This Item

Wzór liniowy:
[CH3(CH2)3]4NF
Numer CAS:
Masa cząsteczkowa:
261.46
Beilstein:
3762762
Numer MDL:
Kod UNSPSC:
12352116
Identyfikator substancji w PubChem:
NACRES:
NA.22

188,00 zł


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Formularz

liquid

Poziom jakości

stężenie

1.0 M in THF

zanieczyszczenia

~5 wt. % water

gęstość

0.903 g/mL at 25 °C

grupa funkcyjna

amine

temp. przechowywania

2-8°C

ciąg SMILES

[F-].CCCC[N+](CCCC)(CCCC)CCCC

InChI

1S/C16H36N.FH/c1-5-9-13-17(14-10-6-2,15-11-7-3)16-12-8-4;/h5-16H2,1-4H3;1H/q+1;/p-1

Klucz InChI

FPGGTKZVZWFYPV-UHFFFAOYSA-M

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Zastosowanie

Reactant for preparation of:
  • Triple monoamine reuptake inhibitors as a new generation of antidepressants
  • Alcohols via hydrolysis of alkyl silyl ethers neutral pH in mixed organic-aqueous buffered solutions
  • Oligoribonucleotides with phosphonate-modified linkages
  • Aryl alkyl alcohols via Nozaki-Hiyama allylation catalyzed by chiral bipyridyldiol ligands and chromium trichloride
  • Conjugated dienoic acid esters using Suzuki coupling reactions
  • Macrocyclic o-aminobenzamide Hsp90 inhibitorwith antitumor activity
  • Phospshoinositide 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) dual inhibitors
  • Anti-diabetic polyacetylenic glucosides
Tetrabutylammonium fluoride (TBAF) can be used as a reagent:
  • For the deprotection of silyl and N-sulfonyl groups.[1][2]
  • In the fluorination reactions.[1]
  • To synthesize 2-substituted indoles by cyclization reaction of various 2-ethynylanilines with terminal alkynes using Pd catalyst.[3] It can also be used as an activator in the synthesis of arylated or alkenylated alkynes by the coupling reaction of aryl and alkenyl halides with terminal alkynes in the presence of Pd catalyst.[4]

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Hasło ostrzegawcze

Danger

Zwroty wskazujące rodzaj zagrożenia

Klasyfikacja zagrożeń

Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Flam. Liq. 2 - Repr. 2 - Skin Irrit. 2 - STOT SE 3

Organy docelowe

Central nervous system, Respiratory system

Zagrożenia dodatkowe

Kod klasy składowania

3 - Flammable liquids

Klasa zagrożenia wodnego (WGK)

WGK 3

Temperatura zapłonu (°F)

1.4 °F - closed cup

Temperatura zapłonu (°C)

-17 °C - closed cup


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Klienci oglądali również te produkty

Deprotection of N-sulfonyl nitrogen-heteroaromatics with tetrabutylammonium fluoride
Yasuhara A and Sakamoto T
Tetrahedron Letters, 39(7), 595-596 (1998)
Tetrabutylammonium Fluoride
Li Hui-Yin, et al.
Encyclopedia of Reagents for Organic Synthesis, Second Edition (2001)
Convenient synthesis of 2-substituted indoles from 2-ethynylanilines with tetrabutylammonium fluoride
Yasuhara A, et al.
Journal of the Chemical Society. Perkin Transactions 1, 39(4), 529-534 (1999)
Non-Sonogashira-type palladium-catalyzed coupling reactions of terminal alkynes assisted by silver (I) oxide or tetrabutylammonium fluoride.
Mori A, et al.
Organic Letters, 2(19), 2935-2937 (2000)
R Bryan Sears et al.
Journal of inorganic biochemistry, 121, 77-87 (2013-01-29)
The complex cis-[Ru(phpy)(phen)(CH3CN)2](+) (phpy=2-phenylpyridine, phen=1,10-phenanthroline) was investigated as a potential photodynamic therapy (PDT) agent. This complex presents desirable photochemical characteristics including a low energy absorption tail extending into the PDT window (600-850nm) and photoinduced exchange of the CH3CN ligands, generating

Produkty

Click chemistry, and the copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) in particular, is a powerful new synthetic tool in polymer chemistry and material science.

Questions

1–7 of 7 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  3. Is the Product 216143 suresealed?

    1 answer
    1. The 5 mL quantity is packaged in an amber glass bottle with a screw cap. All other sizes are packaged with the Sure/Seal capping system.

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  4. What causes Product 216143, Tetrabutylammonium fluoride solution, to turn purple?

    1 answer
    1. Our specifications for this product indicate the material should be colorless to yellow in color. Contact with ketones will immediate discoloration sometimes appearing purple in color.

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  5. What applications can 216143 Tetrabutylammonium fluoride solution, be used in?

    1 answer
    1. This product can be used as a fluorinating reagent.

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  6. What is the Department of Transportation shipping information for this product?

    1 answer
    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

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  7. How should Product 216143, Tetrabutylammonium fluoride solution be stored?

    1 answer
    1. This product is hygroscopic and should be stored under inert gas, such as nitrogen, and at 2-8 deg C, which is in accordance with our MSDS.

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