E7879

β-Estradiol 17-acetate

≥99%

• 別名: 1,3,5(10)-Estratriene-3,17β-diol 17-acetate, 3,17β-Dihydroxy-1,3,5(10)-estratriene 17-acetate
• 実験式（ヒル表記法）: C₂₀H₂₆O₃
• CAS番号: 1743-60-8
• 分子量: 314.42
• Beilstein: 2625732
• MDL番号: MFCD00056537
• UNSPSCコード: 12352200
• PubChem Substance ID: 24894658
• NACRES: NA.77

特性

• 無菌性: non-sterile
• アッセイ: ≥99%
• フォーム: powder
• 溶解性: chloroform: 50 mg/mL, clear, colorless to faintly brownish-yellow
• 輸送温度: ambient
• 保管温度: room temp
• SMILES記法: CC(=O)O[C@H]1CC[C@H]2[C@@H]3CCc4cc(O)ccc4[C@H]3CC[C@]12C
• InChI: 1S/C20H26O3/c1-12(21)23-19-8-7-18-17-5-3-13-11-14(22)4-6-15(13)16(17)9-10-20(18,19)2/h4,6,11,16-19,22H,3,5,7-10H2,1-2H3/t16-,17-,18+,19+,20+/m1/s1
• InChI Key: QAHOQNJVHDHYRN-SLHNCBLASA-N

詳細

アプリケーション

β-Estradiol 17-acetate has been used in body burden analyses, to study the effect of triclosan on an estuarine fish.[1]

生物化学的／生理学的作用

β-Estradiol is a steroid hormone involved in a number of organ functions. It is significantly associated with brain functions including neuroprotection, neurogenesis and synaptic plasticity.[2] β-Estradiol maintains bone homeostasis, and hence is preferred for osteoporosis therapy.[3] 17-β-Estradiol is the most active estrogen generated in our body.[4] During postmenopausal, 17-β-estradiol inhibits oxidative modification in low density lipoprotein. This indicates that estrogen replacement therapy might be useful in treating cardiovascular disease.[5]

特徴および利点

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

安全性情報

• ピクトグラム: GHS08,GHS09
• シグナルワード: Danger
• 危険有害性情報: H360FD,H410
• 注意書き: P202 - P273 - P280 - P308 + P313 - P391 - P405
• 危険有害性の分類: Aquatic Chronic 1 - Repr. 1B
• 保管分類コード: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• 個人用保護具 (PPE): Eyeshields, Gloves, type P3 (EN 143) respirator cartridges