This material is quite soluble in water. The rate of solubility in water has not been established. However, other sources report rates up to 560 mg/mL. Solutions prepared in water are stable when refrigerated at 2-8 °C for at least 60 days. Avoid storing solutions prepared in isotonic buffers, as the literature indicates a possible increase in the rate of decomposition.
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フォーム
powder
品質水準
比活性
≥19,000 IU/mg
抗生物質活性スペクトル
Gram-negative bacteria
作用機序
cell membrane | interferes
保管温度
2-8°C
SMILES記法
[S](=O)(=O)(O)O.N1[C@H](C(=O)NCC[C@@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C1=O)CCN)CCN)CC(C)C)CC(C)C)CCN)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CCCCC(CC)C)CCN)[C@H](O)C)CCN)[C@H](O)C
InChI
1S/C53H100N16O13.H2O4S/c1-9-30(6)12-10-11-13-41(72)60-33(14-20-54)48(77)69-43(32(8)71)53(82)65-36(17-23-57)45(74)64-38-19-25-59-52(81)42(31(7)70)68-49(78)37(18-24-58)62-44(73)34(15-21-55)63-50(79)39(26-28(2)3)67-51(80)40(27-29(4)5)66-46(75)35(16-22-56)61-47(38)76;1-5(2,3)4/h28-40,42-43,70-71H,9-27,54-58H2,1-8H3,(H,59,81)(H,60,72)(H,61,76)(H,62,73)(H,63,79)(H,64,74)(H,65,82)(H,66,75)(H,67,80)(H,68,78)(H,69,77);(H2,1,2,3,4)/t30?,31-,32-,33+,34+,35+,36+,37+,38+,39+,40-,42+,43+;/m1./s1
InChI Key
ZJIWRHLZXQPFAD-LRYSGCCDSA-N
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詳細
化学構造：ペプチド
アプリケーション
生物化学的／生理学的作用
作用機序:グラム陰性菌の細胞膜上の脂質に結合し、細胞壁の構造を破壊します。
抗菌スペクトル:グラム陰性菌。
抗菌スペクトル:グラム陰性菌。
作用機序：グラム陰性菌の細胞膜上の脂質に結合し、細胞壁の完全性を破壊します。
抗菌スペクトル： グラム陰性細菌。コリスチンの腎臓再吸収は、有機カチオントランスポーターおよびペプチドトランスポーターを必要とすること、ならびにこの方法はpHの影響を受けやすいことが示唆されています[2]。
抗菌スペクトル： グラム陰性細菌。コリスチンの腎臓再吸収は、有機カチオントランスポーターおよびペプチドトランスポーターを必要とすること、ならびにこの方法はpHの影響を受けやすいことが示唆されています[2]。
アナリシスノート
水に溶けやすく、アセトンおよびエタノールにほとんど溶けません（96％）
その他情報
容器は密封し、乾燥した換気のよい場所で保管してください。
関連製品
製品番号
詳細
価格
シグナルワード
Danger
危険有害性情報
危険有害性の分類
Acute Tox. 3 Oral
保管分類コード
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
引火点(°F)
Not applicable
引火点(℃)
Not applicable
個人用保護具 (PPE)
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
C4461-1G:
C4461-VAR:
C4461-BULK:
C4461-100MG:
最新バージョンのいずれかを選択してください：
試験成績書（COA）
Lot/Batch Number
この製品を見ている人はこちらもチェック
Mehri Haeili et al.
Microbial drug resistance (Larchmont, N.Y.), 24(9), 1271-1276 (2018-03-29)
Colistin is considered a last-hope antibiotic against extensively drug-resistant isolates of Acinetobacter baumannii. Resistance to colistin has been rarely reported for A. baumannii. Genetic alterations in the PmrA-PmrB two-component system and lipid A biosynthesis genes may be associated with colistin
Anna Ebbensgaard et al.
Frontiers in microbiology, 9, 2153-2153 (2018-09-25)
Bacterial resistance to classical antibiotics is emerging worldwide. The number of infections caused by multidrug resistant bacteria is increasing and becoming a serious threat for human health globally. In particular, Gram-negative pathogens including multidrug resistant Escherichia coli are of serious
Candace M Marr et al.
Frontiers in microbiology, 11, 595798-595798 (2020-11-17)
Acinetobacter baumannii is a problematic pathogen due to its common expression of extensive drug resistance (XDR) and ability to survive in the healthcare environment. These characteristics are mediated, in part, by the signal transduction system BfmR/BfmS. We previously demonstrated, in
Deepesh Nagarajan et al.
Science advances, 5(7), eaax1946-eaax1946 (2019-07-30)
Drug resistance is a public health concern that threatens to undermine decades of medical progress. ESKAPE pathogens cause most nosocomial infections, and are frequently resistant to carbapenem antibiotics, usually leaving tigecycline and colistin as the last treatment options. However, increasing
Peng Cui et al.
Antimicrobial agents and chemotherapy, 60(11), 6867-6871 (2016-09-08)
Persisters are small populations of quiescent bacterial cells that survive exposure to bactericidal antibiotics and are responsible for many persistent infections and posttreatment relapses. However, little is known about how to effectively kill persister bacteria. In the work presented here
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1. What is the solubility of this antibiotic in water? How many mg of the substance can dissolve in 1 mL of water? 2. After preparing a diluted solution of the antibiotic in water, where should it be stored, and what is the recommended storage duration?
1 回答-
役に立ちましたか？
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How is shipping temperature determined? And how is it related to the product storage temperature?
1 回答-
Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf
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How can I determine the shelf life / expiration / retest date of this product?
1 回答-
If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf役に立ちましたか？
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what is potency in microgram/mg?
1 回答-
As per the International Standard Preparation (1968), for comparative purposes, each microgram (ug) of colistin base is equivalent to 30 units. As an example, a lot reporting an activity of 22,891 units/mg would have the equivalent of 763 ug of colistin base per mg solid. This product has a minimum activity specification of 19,000 IU/mg, which equates to 633 ug colistin base per mg solid. The activity is reported on a lot specific basis on the product Certificate of Analysis. Please see the link below to review a sample or lot specific Certificate.
https://www.sigmaaldrich.com/product/sigma/c4461#product-documentation役に立ちましたか？
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What is the recommended storage temperature for the powder after opening the bottle and weighing 10 mg?
1 回答-
The product should be stored at 2-8°C both before and after it is opened.
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May you please indicate if this product is from a biological source or if it is synthesized? Many thanks
1 回答-
Currently, this product is produced from an animal component free microbial fermentation process. A lot specific Certificate of Origin can be supplied by our Technical Service team who can assist you with further. We kindly ask you to navigate to the link https://www.sigmaaldrich.com/techservice, click on "Product Documentation" under the Products Section with all the required information so that a member of our team can reach out to you to assist further. Thank you.
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What is the molecular weight?
1 回答-
The average molecular weight is 1155.4 g/mol.
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After opening the bottle and weigh 10 mg of powder what about storage of powder after opening in refrigerator or no ?
1 回答-
This product should be stored in 2-8°C before and after opening.
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