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SML0273

Sigma-Aldrich

VAS2870

≥97% (HPLC)

Sinonimo/i:

1,3-Benzoxazol-2-yl-3-benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl sulfide, 7-(1,3-Benzoxazol-2-ylsulfanyl)-3-benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidine, 7-(2-Benzoxazolylthio)-3-(phenylmethyl)-3H-1,2,3-triazolo[4,5-d]pyrimidine, VAS 2870, VAS-2870

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5 MG
94,10 €
25 MG
375,00 €

94,10 €

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Cambia visualizzazione
5 MG
94,10 €
25 MG
375,00 €

About This Item

Formula empirica (notazione di Hill):
C18H12N6OS
Numero CAS:
722456-31-7
Peso molecolare:
360.39
Numero MDL:
MFCD03407188
Codice UNSPSC:
12352200
ID PubChem:
329825281
NACRES:
NA.77

94,10 €

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Saggio

≥97% (HPLC)

Stato

powder

Colore

white to beige

Solubilità

DMSO: ≥5 mg/mL

Temperatura di conservazione

room temp

Stringa SMILE

C(c1ccccc1)n2nnc3c(Sc4nc5ccccc5o4)ncnc23

InChI

1S/C18H12N6OS/c1-2-6-12(7-3-1)10-24-16-15(22-23-24)17(20-11-19-16)26-18-21-13-8-4-5-9-14(13)25-18/h1-9,11H,10H2
HZSOKHVVANONPV-UHFFFAOYSA-N

Categorie correlate

Applicazioni

VAS2870 has been used as a nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX) inhibitor:
  • to study the importance of NOX-derived reactive oxygen species in cytoskeletal organization, proper localization of E-cadherin and cell motility during zebrafish epiboly[1]
  • to study the function of Nox2 and Nox4 in lipopolysaccharide (LPS)-induced intestinal injury in high-fat diet (HFD) fed mice[2]
  • to reduce the reactive oxygen species level and study its influence on inhibiting the induction of trained innate immunity in monocytes[3]

Azioni biochim/fisiol

In addition to NOX4 inhibition, VAS2870 is also known to supress the reactive oxygen species (ROS) production in several cell types.[4] It effectively impairs cell growth and increases apoptosis induced by transforming growth factor β (TGF-β) in liver cancer cells. Thus, inhibition of NOX enzymes by VAS2870 may be considered as a potential therapeutic strategy for liver cancer.[5]
VAS2870 is a cell-permeable and specific NADPH oxidase (NOX) inhibitor that effectively suppresses growth factor-mediated ROS liberation in VSMC.
VAS2870 is a cell-permeable and specific NADPH oxidase (NOX) inhibitor.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

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Certificati d'analisi (COA)

Lot/Batch Number
0000289200
0000289200
125M4739V
035M4714V

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Apocynin phyproof® Reference Substance

PHL83252

Apocynin

Myeloperoxidase Inhibitor-I The Myeloperoxidase Inhibitor-I, also referenced under CAS 5351-17-7, controls the biological activity of Myeloperoxidase. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.

Sigma-Aldrich

475944

Myeloperoxidase Inhibitor-I

N,N′-Dimethyl-9,9′-biacridinium dinitrate used as chemiluminescent reagent

Sigma-Aldrich

M8010

N,N′-Dimethyl-9,9′-biacridinium dinitrate

Acetovanillone ≥98%, FG

Sigma-Aldrich

W508454

Acetovanillone

Yahya Sohrabi et al.
Frontiers in immunology, 9, 3155-3155 (2019-02-07)
Introduction: Cells of the innate immune system particularly monocytes and macrophages have been recognized as pivotal players both during the initial insult as well as the chronic phase of atherosclerosis. It has recently been shown that oxidized low-density lipoprotein (oxLDL)
Qi-An Sun et al.
Free radical biology & medicine, 52(9), 1897-1902 (2012-03-13)
Specific inhibitors of the production of reactive oxygen species (ROS) by the NADPH oxidases (Nox's) are potentially important therapeutic agents in the wide range of human diseases that are characterized by excessive ROS production. It has been proposed that VAS2870
Austin T Robinson et al.
American journal of physiology. Heart and circulatory physiology, 312(5), H896-H906 (2017-02-27)
High blood pressure has been shown to elicit impaired dilation in the vasculature. The purpose of this investigation was to elucidate the mechanisms through which high pressure may elicit vascular dysfunction and determine the mechanisms through which regular aerobic exercise
Patricia Sancho et al.
Biochemical pharmacology, 81(7), 917-924 (2011-02-01)
Liver tumor cells show several molecular alterations which favor pro-survival signaling. Among those, we have proposed the NADPH oxidase NOX1 as a prosurvival signal for liver tumor cells. On the one side, we have described that FaO rat hepatoma cells
Jing Yang et al.
International journal of molecular medicine, 42(1), 123-130 (2018-04-06)
NADPH oxidases (NOXs) are important in the pathophysiology of fibrotic diseases. The expression and activity of NOXs are regulated by growth factors, including transforming growth factor (TGF‑β). The proliferation of retinal pigment epithelial (RPE) cells following epithelial‑ to‑mesenchymal transition (EMT) is
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