568533-U
Discovery® HS C18 (5 µm) HPLC Columns
L × I.D. 25 cm × 10 mm, HPLC Column
Szinonimák:
Discovery RP18 HPLC Column
Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez
Összes fotó(1)
About This Item
UNSPSC kód:
41115700
eCl@ss:
32110501
NACRES:
SB.52
H × belső átmérő:
25 cm × 10 mm
külső felület:
300 m2/g
részecskeméret:
5 μm
mátrix aktív csoport:
C18 (octadecyl) phase
pórusméret:
120 Å
Mátrix:
silica gel, high purity, spherical particle platform
fully porous particle
fully porous particle
Javasolt termékek
Terméknév
Discovery® HS C18 HPLC Column, 5 μm particle size, L × I.D. 25 cm × 10 mm
material
stainless steel column
Minőségi szint
Ügynökség
suitable for USP L1
termékcsalád
Discovery®
Jellemzők
endcapped
gyártó/kereskedő neve
Discovery®
kiszerelés
1 ea of
a címkézés mértéke
20% Carbon loading
parameter
≤70 °C temp. range
400 bar pressure (5801 psi)
technika/technikák
HPLC: suitable
H × belső átmérő
25 cm × 10 mm
külső felület
300 m2/g
felület bevonatolás
3.2 μmol/m2
szennyeződések
<10 ppm metals
Mátrix
silica gel, high purity, spherical particle platform
fully porous particle
mátrix aktív csoport
C18 (octadecyl) phase
részecskeméret
5 μm
pórusméret
120 Å
Üzemi pH tartomány
2-8
alkalmazás(ok)
food and beverages
elválasztástechnika
reversed phase
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Általános leírás
Discovery® HS C18 HPLC column is specifically developed for pharmaceutical analyses and purification.
Alkalmazás
- Stereoselective separation of omeprazole and 5-hydroxy-omeprazole using dried plasma spots and a heart-cutting 2D-LC approach for accurate CYP2C19 phenotyping: This research utilizes the Discovery® HS C18 HPLC column for its superior selectivity and sensitivity in pharmacogenetic studies, providing vital data for personalized medicine approaches in drug metabolism (Abouir et al., 2024).
- A stability indicating RP-HPLC method for determination of the COVID-19 drug molnupiravir applied using nanoformulations in permeability studies: This study highlights the effectiveness of the Discovery® HS C18 column in the rapid and accurate analysis of molnupiravir, emphasizing its role in supporting fast-paced pharmaceutical research and development (Reçber et al., 2022).
- Sensitive Analysis of Idarubicin in Human Urine and Plasma by Liquid Chromatography with Fluorescence Detection: This application underlines the Discovery® HS C18 column′s high sensitivity and robustness in clinical diagnostics, crucial for monitoring therapeutic drugs and their metabolites in complex biological matrices (Maliszewska et al., 2020).
Tulajdonságok és előnyök
- Stable, low bleed for LC-MS applications
- Scalable from analytical to preparatory
- Highly stable to ensure excellent run-to-run and lot-to-lot reproducibility
- Higher hydrophobicity for better resolution of difficult analytes
Jogi információk
Discovery is a registered trademark of Merck KGaA, Darmstadt, Germany
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Jolanta Flieger et al.
Journal of separation science, 34(7), 733-739 (2011-03-02)
Highly hydrophilic compounds belonging to biogenic amines were analysed in the reversed-phase system, modified with the addition of ionic liquids: 1-ethyl-3-methyl-imidazolium hexafluorophosphate (EMIM PF(6)) and chaotropic salt NaPF(6) on Discovery HS C18 column at acidic conditions. The effect of the
Swati Jaiswal et al.
Journal of chromatographic science, 55(6), 617-624 (2017-03-24)
Tuberculosis (TB) with human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome represents the most common infectious diseases worldwide. Anti-TB drugs are used concurrently with antiretroviral drug for treatment of TB-HIV co-morbidities. Due to lower risk of interaction with protease inhibitors, rifabutin is
Bhavin N Patel et al.
Biomedical chromatography : BMC, 22(11), 1213-1224 (2008-07-25)
A simple, precise and accurate assay for the determination of 6-methoxy-2-naphthylacetic acid (6-MNA), an active metabolite of nabumetone in human plasma, was developed and validated using liquid chromatography-tandem mass spectrometry (LC-MS/MS). The analyte (6-MNA) and propranolol (internal standard, IS) were
Fazli Khuda et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 944, 114-122 (2013-12-10)
A simple, specific, precise and rapid RP-HPLC-UV method was developed for simultaneous determination of lumefantrine and its metabolite desbutyl lumefantrine in human plasma. Experimental parameters were optimized and the method was validated according to standard guidelines. The method showed adequate
Abad Khan et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 878(28), 2782-2788 (2010-09-11)
A rapid, inexpensive, sensitive and specific HPLC-ECD method for the determination of lipoic acid in human plasma was developed and validated over the linearity range of 0.001-10μg/ml using naproxen sodium as an internal standard (IS). Extraction of lipoic acid and
Related Content
HPLC DiscoveryBIO HS C18 products. Available in 3µm, 5µm and 10µm particle sizes.
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