T3634

(+)-α-Tocopherol

from vegetable oil, Type V, ~1000 IU/g

• Szinonimák: 2,5,7,8-Tetramethyl-2-(4′,8′,12′-trimethyltridecyl)-6-chromanol, 5,7,8-Trimethyltocol, D-α-Tocopherol, Vitamin E
• Tapasztalati képlet (Hill-képlet): C₂₉H₅₀O₂
• CAS-szám: 59-02-9
• Molekulatömeg: 430.71
• Beilstein: 4712525
• EC-szám: 200-412-2
• MDL-szám: MFCD00072045
• UNSPSC kód: 12352205
• eCl@ss: 34058016
• PubChem Substance ID: 24900154
• NACRES: NA.79

Tulajdonságok

• biológiai forrás: vegetable oil
• Minőségi szint: 200
• típus: Type V
• Forma: viscous liquid
• specifikus aktivitás: ~1000 IU/g
• szín: clear yellow to red
• törésmutató: n20/D 1.505 (lit.)
• bp: 200-220 °C/0.1 mmHg (lit.)
• sűrűség: 0.95 g/mL at 25 °C (lit.)
• tárolási hőmérséklet: −20°C
• SMILES string: CC(C)CCC[C@@H](C)CCC[C@@H](C)CCC[C@]1(C)CCc2c(C)c(O)c(C)c(C)c2O1
• InChI: 1S/C29H50O2/c1-20(2)12-9-13-21(3)14-10-15-22(4)16-11-18-29(8)19-17-26-25(7)27(30)23(5)24(6)28(26)31-29/h20-22,30H,9-19H2,1-8H3/t21-,22-,29-/m1/s1
• Nemzetközi kémiai azonosító kulcs: GVJHHUAWPYXKBD-IEOSBIPESA-N

Leírás

Általános leírás

α-Tocopherol is synthesized from γ-tocopherol by the action of enzyme γ-tocopherol methyltransferase. It is the major form of Vitamin E in human plasma. It is present in sunflower seed oil.

Alkalmazás

(+)-α-Tocopherol has been used:

• as a food supplement for juvenile cobia fish
• to evaluate its protective effect on bisphenol A induced oxidative stress in rats
• to test its chemopreventive efficacy in estrogen-mediated mammary cancer rats

Biokémiai/fiziológiai hatások

α-Tocopherol is essential for the photosynthesis in Synechocystis sp. strain PCC 6803. Supplementation with α-Tocopherol decreases lipid peroxidation and platelet aggregation. It inhibits protein kinase C and may play key role in gene regulation.

Tocopherols (TCP) (vitamin E) are a series (α, β, γ and δ) of chiral organic molecules that vary in their degree of methylation of the phenol moiety of the chromanol ring. Tocopherols are lipid soluble anti-oxidants that protect cell membranes from oxidative damage. α-Tocopherol is the form of tocopherol preferentially absorbed by homo sapiens. Various isofroms and analogues of tocopherol have opposing and differentiated regulatory activities in vivo.

Kiszerelés

Packaged under argon in a sealed ampule.

Egyéb megjegyzések

Mixed constitutional (α, β, γ, δ) isomers.

Minőség

Approx. 670 mg D-α-tocopherol per gram. The non-α content is typically between 5-35 mg/g

Vigyázat

Subject to air oxidation.

Fizikai tulajdonságok

This product is miscible with chloroform or ethanol. It is practically insoluble in water but it is miscible with ether, acetone, and vegetable oils. It is unstable to alkaline conditions.

Biztonsági adatok

• Tárolási osztály kódja: 10 - Combustible liquids
• WGK: WGK 1
• Lobbanási pont (F): 230.0 °F - closed cup
• Lobbanási pont (C): 110 °C - closed cup
• Egyéni védőeszköz: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)