Összes fotó(4)
Fontos dokumentumok
T1001
Thyroglobulin from bovine thyroid
powder, ≥90% (agarose gel electrophoresis)
Szinonimák:
Globulins thyro, Thyractin
Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez
Összes fotó(4)
About This Item
Javasolt termékek
biológiai forrás
bovine thyroid
Minőségi szint
Teszt
≥90% (agarose gel electrophoresis)
Forma
powder
molekulatömeg
~670 kDa
összetétel
Iodine, ≥0.20%
nitrogén analízis
13.0-16.0% total
hamu
≤4%
oldhatóság
H2O: 20 mg/mL
UniProt elérési szám
tárolási hőmérséklet
−20°C
Géninformáció
cow ... TG(280706)
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Alkalmazás
Bovine thyroglobulin was shown to stimulate proliferation in rat thyroid follicular cells as well as in primary porcine thyroid epithelial cells. This effect was mediated through PI3K signaling.
Often used as a carrier protein for the production of antibodies. Its advantage is the large number of tyrosine residues that can be used for conjugation using the diazo reaction.
Biokémiai/fiziológiai hatások
Bovine thyroglobulin is a large, tetrameric glycoprotein produced in the thyroid gland as a precursor to thyroid hormones. Its large size and absence from plasma under normal conditions makes it very immunogenic and reduces the chance that antibodies to this carrier protein will cross-react with plasma proteins in immunoassays. Haptens may be conjugated to thyroglobulin via accessible secondary amines.
Iodine-containing protein that is stored in the thyroid gland. Converted into circulating thyroxines when the thyroid is stimulated by thyroid-stimulating hormone (TSH) from the pituitary. Because its expression is unique to the thyroid, it is a sensitive indicator of recurrence or metastasis of thyroid cancer that has been treated by thyroid ablation.
Tárolási osztály kódja
11 - Combustible Solids
WGK
WGK 3
Lobbanási pont (F)
Not applicable
Lobbanási pont (C)
Not applicable
Egyéni védőeszköz
Eyeshields, Gloves, type N95 (US)
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