SRP8052

CD279 (human): FC (human)

recombinant, expressed in CHO cells, ≥98% (SDS-PAGE)

• Szinonimák: Hepatitis A virus cellular receptor 2, PD-1, Programmed cell death protein 1
• UNSPSC kód: 12352200
• NACRES: NA.32

Tulajdonságok

• biológiai forrás: human
• rekombináns: expressed in CHO cells
• Teszt: ≥98% (SDS-PAGE)
• form: lyophilized
• molekulatömeg: monomer 46 kDa by calculation
• kiszerelés: pkg of 100 μg
• szennyeződések: <0.06 EU/μg endotoxin, tested
• UniProt elérési szám: Q15116
• kiszállítva: wet ice
• tárolási hőmérséklet: −20°C
• Géninformáció: human ... PDCD1(5133)

Leírás

Általános leírás

Programmed Death-1 (PD-1, CD279) is a type I transmembrane protein belonging to the CD28/CTLA-4 family of immunoreceptors that mediate signals for regulating immune responses. Members of the CD28/CTLA-4 family have been shown to either promote T cell activation (CD28 and ICOS) or downregulate T cell activation (CTLA-4 and PD-1). CD279 is expressed on activated T-cells, B-cells, myeloid cells and on a subset of thymocytes. In vitro, ligation of CD279 inhibits TCR-mediated T-cell proliferation and production of IL-1, IL-4, IL-10 and IFN-γ. In addition, CD279 ligation also inhibits BCR mediated signaling. CD279 deficient mice have a defect in peripheral tolerance and spontaneously develop autoimmune diseases.

Fizikai forma

Lyophilized from 0.2 μm-filtered solution in PBS.

Feloldás

Reconstitute at 100 μg/mL in sterile PBS.

Egyéb megjegyzések

The extracellular domain of human CD279 [PD-1] (aa 25-167) is fused to the N-terminus of the Fc region of human IgG1.

Biztonsági adatok

• Tárolási osztály kódja: 10 - Combustible liquids
• WGK: WGK 2
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable