SRP8026
Annexin V human
recombinant, expressed in E. coli, GST tagged, ≥95% (SDS-PAGE)
Szinonimák:
Annexin A5, Calphobindin I, EC 2.7.1.23, Endonexin II, Placental anticoagulantprotein I
Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez
Összes fotó(1)
About This Item
UNSPSC kód:
12352200
NACRES:
NA.32
Javasolt termékek
biológiai forrás
human
rekombináns
expressed in E. coli
tag
GST tagged
Teszt
≥95% (SDS-PAGE)
form
lyophilized
molekulatömeg
~52 kDa
kiszerelés
pkg of 100 μg
tárolási körülmény
avoid repeated freeze/thaw cycles
technika/technikák
activity assay: suitable
szín
white
UniProt elérési szám
kiszállítva
wet ice
tárolási hőmérséklet
−20°C
Géninformáció
human ... ANXA5(308)
Általános leírás
Annexin V is a member of the annexin family of calcium and membrane-binding proteins that have anticoagulatory and anti-inflammatory properties. The encoded protein is 320 amino acid long and is folded into four domains, each having five α-helices, forming a superhelical globular structure. The ANX5 gene is mapped to human chromosome 4q26-q28 and spans a length of 28kb containing 13 exons and 12 introns.
Alkalmazás
Annexin V has been used to examine phosphorylation activity of ChaK1 (channel-kinase 1).
Biokémiai/fiziológiai hatások
Annexins are a family of water-soluble proteins that bind to membranes and phospholipids in a calcium-dependent manner. They participate in several cellular functions, such as membrane fusion and cytoskeletal interaction. Annexin V is a potent anticoagulant and serves as a voltage-gated calcium channel when bound to membrane in vitro. It is found to inhibit phospholipase A2 and protein kinase C.
Fizikai forma
Lyophilized from PBS, pH 7.4.
Feloldás
Reconstitute with 100 μL deionized water.
Egyéb megjegyzések
Recombinant human annexin V fused to a GST-tag.
Tárolási osztály kódja
10 - Combustible liquids
WGK
WGK 3
Lobbanási pont (F)
Not applicable
Lobbanási pont (C)
Not applicable
Analitikai tanúsítványok (COA)
Analitikai tanúsítványok (COA) keresése a termék sarzs-/tételszámának megadásával. A sarzs- és tételszámok a termék címkéjén találhatók, a „Lot” vagy „Batch” szavak után.
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Az Ön által nemrégiben megvásárolt termékekre vonatkozó dokumentumokat a Dokumentumtárban találja.
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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 83, 130-140 (2016-10-25)
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Journal of thrombosis and thrombolysis, 48(2), 195-202 (2019-06-09)
Thromboembolic events are frequent and serious complications of acute lymphoblastic leukaemia treatment. The importance of chemotherapy in the pathogenesis of this increased risk is enhanced by the fact that thrombosis rarely occurs at diagnosis. Our study aims at investigating the
Marielle E Yohe et al.
Science translational medicine, 10(448) (2018-07-06)
The RAS isoforms are frequently mutated in many types of human cancers, including PAX3/PAX7 fusion-negative rhabdomyosarcoma. Pediatric RMS arises from skeletal muscle progenitor cells that have failed to differentiate normally. The role of mutant RAS in this differentiation blockade is
Xuerui Zhang et al.
Oncotarget, 8(26), 42602-42612 (2017-04-14)
Annexin V, a protein with high affinity to phosphatidylserine (PS) in a calcium dependent manner, has been widely used to probe apoptosis. Annexin V in inhibiting engulfment of apoptotic cells by macrophages had been reported to increase the immunogenicity of
Lei Huang et al.
Oxidative medicine and cellular longevity, 2020, 4921562-4921562 (2020-08-28)
Neuroinflammation plays an important pathological role in experimental surgical brain injury (SBI). Apoptotic associated with phosphatidylserine (PS) externalization promotes anti-inflammatory mediator TGF-β1 release. In the present study, we investigated the anti-neuroinflammation effect of PS liposome or isoflurane pretreatment via PS/CD36/TGF-β1
Tudóscsoportunk valamennyi kutatási területen rendelkezik tapasztalattal, beleértve az élettudományt, az anyagtudományt, a kémiai szintézist, a kromatográfiát, az analitikát és még sok más területet.
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