SRP3224

MIP-1 alpha (CCL3) from mouse

recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture

• Szinonimák: CCL3, LD78a
• UNSPSC kód: 12352200
• NACRES: NA.32

Tulajdonságok

• biológiai forrás: mouse
• rekombináns: expressed in E. coli
• Teszt: ≥98% (HPLC); ≥98% (SDS-PAGE)
• form: lyophilized
• molekulatömeg: 7.8 kDa
• kiszerelés: pkg of 10 μg
• technika/technikák: cell culture | mammalian: suitable
• szennyeződések: <0.1 EU/μg endotoxin, tested
• szín: white to off-white
• UniProt elérési szám: P10855
• kiszállítva: wet ice
• tárolási hőmérséklet: −20°C
• Géninformáció: mouse ... CCL3(20302)

Leírás

Általános leírás

Both MIP-1α and MIP-1β are structurally and functionally related CC chemokines. They participate in the host response to invading bacterial, viral, parasite and fungal pathogens by regulating the trafficking and activation state of selected subgroups of inflammatory cells e.g. macrophages, lymphocytes and NK cells. While both MIP-1a and MIP-1b exert similar effects on monocytes their effect on lymphocytes differ; with MIP-1a selectively attracting CD8+ lymphocytes and MIP-1b selectively attracting CD4+ lymphocytes. Additionally, MIP-1α and MIP-1β have also been shown to be potent chemoattractants for B cells, eosinophils and dendritic cells. Both human and murine MIP-1α and MIP-1β are active on human and murine hematopoietic cells. Recombinant murine MIP-1α is a 7.8 kDa protein containing 69 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines.

Biokémiai/fiziológiai hatások

Both MIP-1a and MIP-1b are structurally and functionally related CC chemokines. Recombinant murine MIP-1a is a 7.8 kDa protein containing 69 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines.

Szekvencia

APYGADTPTA CCFSYSRKIP RQFIVDYFET SSLCSQPGVI FLTKRNRQIC ADSKETWVQE YITDLELNA

Fizikai forma

Lyophilized with no additives.

Feloldás

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.

Biztonsági adatok

• Tárolási osztály kódja: 11 - Combustible Solids
• WGK: WGK 3
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable