Ugrás a tartalomra
Merck
Összes fotó(1)

Fontos dokumentumok

SML0543

Sigma-Aldrich

p38 MAP Kinase Inhibitor IV

≥98% (HPLC)

Szinonimák:

2,2′-Sulfonyl-bis-(3,4,6-trichlorophenol), B10, MT4

Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez
Összes fotó(1)

About This Item

Tapasztalati képlet (Hill-képlet):
C12H4Cl6O4S
CAS-szám:
1638-41-1
Molekulatömeg:
456.94
UNSPSC kód:
12352200
NACRES:
NA.77
Az árazás és az elérhetőség jelenleg nem elérhető

Minőségi szint

100

Teszt

≥98% (HPLC)

Forma

powder

szín

white to beige

oldhatóság

DMSO: 5 mg/mL, clear (warmed)

tárolási hőmérséklet

2-8°C

SMILES string

[S](=O)(=O)(c2c(c(cc(c2O)Cl)Cl)Cl)c1c(c(cc(c1O)Cl)Cl)Cl

InChI

1S/C12H4Cl6O4S/c13-3-1-5(15)9(19)11(7(3)17)23(21,22)12-8(18)4(14)2-6(16)10(12)20/h1-2,19-20H

Nemzetközi kémiai azonosító kulcs

AKUKHICVNCCQHN-UHFFFAOYSA-N

Alkalmazás

p38 MAP Kinase Inhibitor IV has been used for blocking p38α kinase activation in order to examine if HOXB7 is involved in the regulation of migration and proliferation process via AKT/MAPK signaling.[1]

Biokémiai/fiziológiai hatások

p38 MAP Kinase Inhibitor IV is an ATP-competitive inhibitor of p38α/β MAPK with IC50 values of 130 nM for p38α and 550 nM for p38β. It is much less active with ≤23% inhibition at 1 μM against p38γ/σ, ERK1/2, and JNK1/2/3. Shown to be more effective than SB 203580 in inhibiting LPS-induced IL-1β release from hPBMC (100% vs. 50% inhibition with 100 μM inhibitor). A recent study showed that p38 MAP Kinase Inhibitor IV could consistently and significantly enhance reprogramming and iPS cell generation from somatic cells.
p38 MAP Kinase Inhibitor IV is an ATP-competitive inhibitor of p38α/β MAPK.

Tulajdonságok és előnyök

This compound is featured on the MAPKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Tárolási osztály kódja

11 - Combustible Solids

WGK

WGK 3

Lobbanási pont (F)

Not applicable

Lobbanási pont (C)

Not applicable

Válasszon a legfrissebb verziók közül:

Analitikai tanúsítványok (COA)

Lot/Batch Number
0000158495
0000158495
0000158494
0000124260

Nem találja a megfelelő verziót?

Ha egy adott verzióra van szüksége, a tétel- vagy cikkszám alapján rákereshet egy adott tanúsítványra.

COA keresése

Már rendelkezik ezzel a termékkel?

Az Ön által nemrégiben megvásárolt termékekre vonatkozó dokumentumokat a Dokumentumtárban találja.

Dokumentumtár megtekintése

Az ügyfelek ezeket is megtekintették

Slide 1 of 7

1 of 7

SB 202190 ≥98% (HPLC)

Sigma-Aldrich

S7067

SB 202190

PD 169316 ≥98% (HPLC), solid

Sigma-Aldrich

P9248

PD 169316

SP600125 ≥98% (HPLC)

Sigma-Aldrich

S5567

SP600125

Combretastatin A4 ≥98% (HPLC), powder

Sigma-Aldrich

C7744

Combretastatin A4

Albendazole sulfoxide VETRANAL®, analytical standard

Supelco

35395

Albendazole sulfoxide

PD 98,059 solid

Sigma-Aldrich

P215

PD 98,059

U0126 U0126 is a elective inhibitor of MEK-1 and MEK-2; weak inhibitor of PKC, Raf, ERK, JNK, MEKK, MKK-3, MKK-4/SEK, MKK-6, Abl, Cdk2 and Cdk4.

Sigma-Aldrich

19-147

U0126

Jong-Hwan Woo et al.
Particle and fibre toxicology, 20(1), 2-2 (2023-01-10)
Polypropylene (PP) is used in various products such as disposable containers, spoons, and automobile parts. The disposable masks used for COVID-19 prevention mainly comprise PP, and the disposal of such masks is concerning because of the potential environmental pollution. Recent
Xujun He et al.
Oncotarget, 8(1), 1247-1261 (2016-12-03)
Increased expression of HOXB7 has been reported to correlate with the progression in many cancers. However, the specific mechanism by which it promotes the evolution of gastric cancer (GC) is poorly understood.In this study, we sought to investigate the role
Denis Nchang Che et al.
International immunopharmacology, 83, 106403-106403 (2020-03-21)
IL-31 and IL-33 are cytokines, which are expressed in many inflammatory and pathological disorders, thus suggesting an IL-31/IL-33 axis interaction in pathological diseases. Luteolin from natural products is known for its anti-inflammatory activities associated with the regulation of inflammatory signaling
Hanna Niehues et al.
JID innovations : skin science from molecules to population health, 2(1), 100066-100066 (2022-02-12)
Psoriasis and atopic dermatitis are chronic inflammatory skin diseases characterized by keratinocyte (KC) hyperproliferation and epidermal acanthosis (hyperplasia). The milieu of disease-associated cytokines and soluble factors is considered a mitogenic factor; however, pinpointing the exact mitogens in this complex microenvironment
Douglas P Jasmer et al.
Pharmaceuticals (Basel, Switzerland), 14(7) (2021-07-03)
Establishing methods to investigate treatments that induce cell death in parasitic nematodes will promote experimental approaches to elucidate mechanisms and to identify prospective anthelmintics capable of inducing this outcome. Here, we extended recent progress on a method to monitor cell

Cikkek

Mitogen-activated Protein Kinases (MAPKs)

The mitogen-activated protein kinase (MAPK) family consists of stress-activated (SAPK) and MAPKs. Learn about their network of signal transduction cascades that mediate cellular responses to a diverse range of stimuli.

Questions

Reviews

No rating value

Active Filters

Tudóscsoportunk valamennyi kutatási területen rendelkezik tapasztalattal, beleértve az élettudományt, az anyagtudományt, a kémiai szintézist, a kromatográfiát, az analitikát és még sok más területet.

Lépjen kapcsolatba a szaktanácsadással