SML0038

Fluvastatin sodium hydrate

≥98% (HPLC)

• Szinonimák: (±)-(3R^*,5S^*,6E)-7-[3-(4-Fluorophenyl)-1-(1-methyethyl)-1H-indol-2-yl]-3,5-dihydroxy-6-heptenoic acid sodium salt hydrate
• Tapasztalati képlet (Hill-képlet): C₂₄H₂₅FNO₄ · Na · xH₂O
• CAS-szám: 93957-55-2
• Molekulatömeg: 433.45 (anhydrous basis)
• MDL-szám: MFCD20488050
• UNSPSC kód: 12352204
• PubChem Substance ID: 329825108
• NACRES: NA.77

Tulajdonságok

• Minőségi szint: 100
• Teszt: ≥98% (HPLC)
• Forma: powder
• tárolási körülmény: desiccated
• szín: white to tan
• oldhatóság: H₂O: ≥9 mg/mL
• kezdeményező: Novartis
• tárolási hőmérséklet: 2-8°C
• SMILES string: O.[Na+].CC(C)n1c(\C=C\[C@@H](O)C[C@@H](O)CC([O-])=O)c(-c2ccc(F)cc2)c3ccccc13
• InChI: 1S/C24H26FNO4.Na.H2O/c1-15(2)26-21-6-4-3-5-20(21)24(16-7-9-17(25)10-8-16)22(26)12-11-18(27)13-19(28)14-23(29)30;;/h3-12,15,18-19,27-28H,13-14H2,1-2H3,(H,29,30);;1H2/q;+1;/p-1/b12-11+;;/t18-,19-;;/m1../s1
• Nemzetközi kémiai azonosító kulcs: KKEMYLLTGGQWCE-PMRANXHDSA-M

Leírás

Alkalmazás

Fluvastatin sodium hydrate has been used:

• to examine its effect on β -glucan-induced training on immunity
• to investigate the effect of statins on the number of uncoupling protein 1 (UCP1)⁺ cells
• to determine its effect on insulin degrading enzyme (IDE) secretion from astrocytes
• to treat and study its effect on human umbilical vein endothelial cells (HUVECs) in vitro

Fluvastatin sodium hydrate has been used:

• to test its anti-hepatitis C virus (HCV) activity
• as a cholesterol inhibitor
• to study its effects on β-glucan-induced monocyte immune training

Biokémiai/fiziológiai hatások

Fluvastatin has antifungal activity.

Fluvastatin is a competitive inhibitor of hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase, the enzyme that catalyzes the conversion of HMG-CoA to mevalonic acid, the rate-limiting step in cholesterol biosynthesis. Fluvastatin is antilipemic and is used to reduce plasma cholesterol levels and prevent cardiovascular disease.

Tulajdonságok és előnyök

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Biztonsági adatok

• Tárolási osztály kódja: 11 - Combustible Solids
• WGK: WGK 3
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable