SMB00377

Magnoflorine

≥98% (HPLC)

• Szinonimák: (6aS)-2,10-dimethoxy-6,6-dimethyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-6-ium-1,11-diol
• Tapasztalati képlet (Hill-képlet): C₂₀H₂₄NO₄
• CAS-szám: 2141-09-5
• Molekulatömeg: 342.41
• MDL-szám: MFCD09031380
• UNSPSC kód: 12352205
• PubChem Substance ID: 329824978
• NACRES: NA.25

Tulajdonságok

• Minőségi szint: 200
• Teszt: ≥98% (HPLC)
• Forma: powder
• alkalmazás(ok): metabolomics; vitamins, nutraceuticals, and natural products
• tárolási hőmérséklet: 2-8°C
• SMILES string: OC1=C(OC)C=C2CC[N+](C)(C)[C@@]3([H])CC4=CC=C(OC)C(O)=C4C1=C32
• InChI: 1S/C20H23NO4/c1-21(2)8-7-12-10-15(25-4)20(23)18-16(12)13(21)9-11-5-6-14(24-3)19(22)17(11)18/h5-6,10,13H,7-9H2,1-4H3,(H-,22,23)/p+1/t13-/m0/s1
• Nemzetközi kémiai azonosító kulcs: YLRXAIKMLINXQY-ZDUSSCGKSA-O

Leírás

Általános leírás

Magnoflorine is a secondary metabolite and an alkaloid with a quaternary aporphine configuration. It can be found in roots, rhizomes, stems, barks, or seeds of many herbal plants such as Caulophyllum thalictroides (blue cohosh), Arisolochai bracteate, P. amurense, S. acutum, Tinospora crispa, Coptidis rhizome, etc. Magnoflorine constitutes approximately 65 % of the total alkaloids in roots and rhizomes of blue cohosh. It is also known as thalictrine and escholine.

Alkalmazás

Magnoflorin has been used to test its contractile effects on isolated mouse uterine smooth muscle tissues and on isolated strips of Mus musculus distal colon smooth muscle tissues.

Biokémiai/fiziológiai hatások

Magnoflorine possesses several biochemical and pharmacological properties such as antioxidant, anti-inflammatory, immunomodulatory, anti-diabetic, anti-fungal, cardiovascular protective, and neuropsychological. It also acts as an α-tyrosinase inhibitor. It helps to increase pro-inflammatory responses induced by lipopolysaccharide (LPS). It exerts antitumor, anti-cancer activities by inhibiting gastric cancer progression gastric cancer cell xenograft mouse model.

Biztonsági adatok

• Piktogramok: GHS07
• Figyelmeztetés: Warning
• Figyelmeztető mondatok: H302 + H312 + H332
• Óvintézkedésre vonatkozó mondatok: P261 - P280 - P301 + P312 + P330 - P302 + P352 + P312 - P304 + P340 + P312
• Veszélyességi osztályok: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral
• Tárolási osztály kódja: 11 - Combustible Solids
• WGK: WGK 3
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable