SMB00314

Coptisine Chloride

≥98% (HPLC)

• Szinonimák: Coptisine chloride, Bis(methylenedioxy)protoberberine chloride, Coptisin Chloride
• Tapasztalati képlet (Hill-képlet): C₁₉H₁₄ClNO₄
• CAS-szám: 6020-18-4
• Molekulatömeg: 355.77
• MDL-szám: MFCD00016676
• UNSPSC kód: 12352205
• PubChem Substance ID: 329824946
• NACRES: NA.25

Tulajdonságok

• Minőségi szint: 200
• Teszt: ≥98% (HPLC)
• form: powder
• alkalmazás(ok): metabolomics; vitamins, nutraceuticals, and natural products
• tárolási hőmérséklet: −20°C
• SMILES string: C1(OCO2)=C2C=C(CC[N+]3=C4C=C5C(C(OCO6)=C6C=C5)=C3)C4=C1.[Cl-]
• InChI: 1S/C19H14NO4.ClH/c1-2-16-19(24-10-21-16)14-8-20-4-3-12-6-17-18(23-9-22-17)7-13(12)15(20)5-11(1)14;/h1-2,5-8H,3-4,9-10H2;1H/q+1;/p-1
• Nemzetközi kémiai azonosító kulcs: LUXPUVKJHVUJAV-UHFFFAOYSA-M

Leírás

Általános leírás

Coptisine chloride is a cytotoxic isoquinoline alkaloid. It is the major bioactive compound of Coptis rhizome, and can also be found in different plants such as Chelidonium majus, Enantia chlorantha. Coptisine is related to berberine and has a similar structure to that of Jatrorrhizine.

Alkalmazás

Coptisine Chloride has been used to study its binding interactions with single-stranded poly(A) using different absorbance and thermal melting spectroscopic experiments. It may have been used as a standard to analyze Chelidonium majus L. extracted compounds using UV/VIS absorption spectroscopy.

Biokémiai/fiziológiai hatások

Coptisine Chloride is a potent anti-malarial compound, which also exerts anti-cancer and anti-diabetic properties. It elicits protective effects on gastric mucus membrane and is used as a traditional medicine against gastroenteric diseases. Coptisine chloride also displays anti-microbial activities.It has been analyzed as a cytotoxic agent in hepatoma and leukemic cells and is reported to block cell cycle progression.

Biztonsági adatok

• Piktogramok: GHS06
• Figyelmeztetés: Danger
• Figyelmeztető mondatok: H300 + H330
• Óvintézkedésre vonatkozó mondatok: P260 - P264 - P271 - P284 - P304 + P340 + P310 - P403 + P233
• Veszélyességi osztályok: Acute Tox. 2 Inhalation - Acute Tox. 2 Oral
• Tárolási osztály kódja: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable