SMB00376

CDDO Methyl Ester

≥98% (HPLC)

• Szinonimák: 2-Cyano-3,12-dioxo-oleana-1,9(11)-dien-28-oic acid methyl ester, Bardoxolone Methyl, CDDO-Me
• Tapasztalati képlet (Hill-képlet): C₃₂H₄₃NO₄
• CAS-szám: 218600-53-4
• Molekulatömeg: 505.69
• MDL-szám: MFCD11983137
• UNSPSC kód: 12352205
• PubChem Substance ID: 329824977
• NACRES: NA.25

Tulajdonságok

• Minőségi szint: 200
• Teszt: ≥98% (HPLC)
• Forma: powder
• alkalmazás(ok): metabolomics; vitamins, nutraceuticals, and natural products
• tárolási hőmérséklet: −20°C
• SMILES string: CC1(C)CC[C@]2(C(OC)=O)CC[C@@]([C@@]3([H])[C@]2([H])C1)(C)[C@]4(C)CC[C@@]5([H])C(C)(C)C(C(C#N)=C[C@]5(C)C4=CC3=O)=O
• InChI: 1S/C32H43NO4/c1-27(2)11-13-32(26(36)37-8)14-12-31(7)24(20(32)17-27)21(34)15-23-29(5)16-19(18-33)25(35)28(3,4)22(29)9-10-30(23,31)6/h15-16,20,22,24H,9-14,17H2,1-8H3/t20-,22-,24-,29-,30+,31+,32-/m0/s1
• Nemzetközi kémiai azonosító kulcs: WPTTVJLTNAWYAO-KPOXMGGZSA-N
• Géninformáció: human ... IKBKB(3551) , KEAP1(9817) , NFE2L2(4780) , PPARG(5468)

Leírás

Általános leírás

CDDO-Me is a synthetic triterpenoid compound with anti-inflammatory, anti-tumor and cytoprotective properties. It is derived from the natural product oleanic acid.

Alkalmazás

CDDO Methyl Ester has been used to test its effect on hepatocyte membrane transporters (HMTs) regulation and mitigation of cholestasis in hepatic ischemia-reperfusion injury (IRI). It has also been used activator of NF E2 Related Factor 2 (NRF2) to study its role in preventing cell death in melanoma cells.

Biokémiai/fiziológiai hatások

CDDO-Me inhibits inflammatory mediators including interleukin-6 (IL-6), IL-10, and IL-12. It enhances apoptosis induced by TNF and chemotherapeutic agents. CDDO-Me exhibits anti-proliferative activity in osteosarcoma cells and enhances the effectiveness of chemotherapeutic agents by inducing an intrinsic mitochondrial-dependent apoptotic pathway. It can be used as an adjuvant treatment for advanced and fatal form of prostate cancer.

Biztonsági adatok

• Tárolási osztály kódja: 11 - Combustible Solids
• WGK: WGK 3
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable