S4441

D,L-Sulforaphane

≥90% (HPLC), liquid, phase II detoxification enzymes inducer

• Szinonimák: 1-Isothiocyanato-4-(methylsulfinyl)-butane
• Tapasztalati képlet (Hill-képlet): C₆H₁₁NOS₂
• CAS-szám: 4478-93-7
• Molekulatömeg: 177.29
• MDL-szám: MFCD00198068
• UNSPSC kód: 12352200
• PubChem Substance ID: 24724610
• NACRES: NA.77

Tulajdonságok

• product name: DL-Sulforaphane, ≥90% (HPLC), synthetic, liquid
• biológiai forrás: synthetic
• Minőségi szint: 200
• Teszt: ≥90% (HPLC)
• form: liquid
• oldhatóság: DMSO: soluble 40 mg/mL; H₂O: insoluble
• kompatibilitás: for use with ABI 7500
• kiszállítva: dry ice
• tárolási hőmérséklet: −20°C
• SMILES string: CS(=O)CCCCN=C=S
• InChI: 1S/C6H11NOS2/c1-10(8)5-3-2-4-7-6-9/h2-5H2,1H3
• Nemzetközi kémiai azonosító kulcs: SUVMJBTUFCVSAD-UHFFFAOYSA-N

Leírás

Alkalmazás

LNCaP prostate cancer cells were treated with DL-Sulforaphane to study the effect on androgen receptor. Effects on malathion toxicity was studied in rats by treating them with DL-Sulforaphane.

Biokémiai/fiziológiai hatások

Selective inducer of phase II detoxification enzymes with anticarcinogenic properties. Organosulfur compound found in cruciferous vegetables, including broccoli.

Sulforaphane is an anti-cancer, anti-microbial and anti-diabetic compound found in cruciferous vegetables. It induces the production of detoxifying enzymes such as quinone reductase and glutathione S-transferase that cause xenobiotic transformation. Sulforaphane also increases the transcription of tumor suppressor proteins and inhibits histone deacetylases. It modulates inflammatory responses by suppressing the LPS-mediated expression of iNOS, COX-2, IL-1β and TNF-α.

Biztonsági adatok

• Tárolási osztály kódja: 10 - Combustible liquids
• WGK: WGK 3
• Egyéni védőeszköz: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)