SAB5702238

Anti-PD-L1/CD274 Antibody, clone 8F1V6, Rabbit Monoclonal

• Szinonimák: B7-H,B7H1,PDL1,PD-L1,PDCD1L1,PDCD1LG1,CD274
• UNSPSC kód: 12352203
• NACRES: NA.46

Tulajdonságok

• biológiai forrás: rabbit
• Minőségi szint: 100
• material: colorless
• klón: 8F1V6, monoclonal
• form: liquid
• faj reaktivitás: human
• koncentráció: 0.65 mg/mL
• technika/technikák: flow cytometry: 1:50 - 1:200
• szín: colorless
• izotípus: IgG
• UniProt elérési szám: Q9NZQ7
• kiszállítva: wet ice
• tárolási hőmérséklet: −20°C
• célzott transzláció utáni módosítás: unmodified
• Géninformáció: human ... PD-L1(29126)

Leírás

Általános leírás

Programmed death-ligand 1 (PD-L1) is a 40kDa type 1 transmembrane protein that suppresses immune system. PD-L1 is expressed in hematopoietic and non-hematopoietic cells including T cells and B cells and various types of tumor cells. PD-L1 binds to its receptor Programmed death 1 (PD1). During infection or inflammation, PD1-PD-L1 interaction is important for preventing autoimmunity. In tumor microenvironments, PD1-PD-L1 interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human cancers. In recent years, PD-L1 has become an important biomarker and immunotherapy target for many types of malignancies.

Immunogen

PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.

Recombinant protein of human PD-L1/CD274.

Alkalmazás

ELISA, WB, FC, Inhibition

Biztonsági adatok

• Tárolási osztály kódja: 10 - Combustible liquids
• WGK: WGK 1