S3134

Streptokinase from β-hemolytic Streptococcus (Lancefield Group C)

lyophilized powder, ≥2,000 units/mg solid

• Szinonimák: Streptokinase from Streptococcus hemolyticus
• CAS-szám: 9002-01-1
• Enzyme Commission szám: 3.4.99.0 (BRENDA, IUBMB)
• EC-szám: 232-647-1
• MDL-szám: MFCD00082037
• UNSPSC kód: 12352204
• eCl@ss: 32160410
• NACRES: NA.54

Tulajdonságok

• form: lyophilized powder
• Minőségi szint: 200
• specifikus aktivitás: ≥2,000 units/mg solid
• kiszállítva: wet ice
• tárolási hőmérséklet: −20°C
• InChI: 1S/C11H19NO2/c13-11(14)10-6-9(7-12-10)8-4-2-1-3-5-8/h8-10,12H,1-7H2,(H,13,14)
• Nemzetközi kémiai azonosító kulcs: XRZWVSXEDRYQGC-UHFFFAOYSA-N

Leírás

Általános leírás

Research area: Cell signaling

Streptokinase is an extracellular enzyme produced by β-hemolytic Streptococcus. It is a single-chain polypeptide enzyme that consists of multiple structural domains, including α-, β-, and γ-domains.

Alkalmazás

Streptokinase has been used in a study to compare primary coronary intervention and thrombolytic therapy in myocardial infarction patients.

Streptokinase is commonly used as a thrombolytic agent in the therapy of ischemic stroke. This therapy carries the important risk of intracerebral hemorrhage. Streptokinase is also used in the treatment of complicated parapneumonic effusions and empyema where adverse reactions, allergic type, are rare.

Biokémiai/fiziológiai hatások

Streptokinase is a potent plasminogen activator. Unlike human proteins tissue plasminogen activator (tPA) and urokinase plasminogen activator (uPA), microbial streptokinase does not directly activate plasminogen. Instead, it activates plasminogen by fibrin-dependent and fibrin-independent. mechanisms. Streptokinase is effective in thrombolytic therapy. While streptokinase offers promising potential in treating ischemic stroke, its use also presents a significant risk of intracerebral hemorrhage. Streptokinase is also used in treating complicated parapneumonic effusions and empyema where allergic reactions, are rare.

Egység definíció

One unit is equal to the amount of activity in one unit from a Streptokinase International Standard reference vial.

Fizikai forma

Lyophilized powder containing ~50% total protein by biuret and sodium glutamate. Total protein composed of enzyme protein and human serum albumin.

Biztonsági adatok

• Tárolási osztály kódja: 11 - Combustible Solids
• WGK: WGK 3
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable