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R4653

Sigma-Aldrich

Anti-hnRNP-A2/B1 antibody, Mouse monoclonal

clone DP3B3, purified from hybridoma cell culture

Szinonimák:

Anti-Heterogeneous Nuclear Ribonucleoprotein-A2/B1

Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez
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About This Item

MDL-szám:
MFCD03845440
UNSPSC kód:
12352203
NACRES:
NA.41

biológiai forrás

mouse

Minőségi szint

200

konjugátum

unconjugated

antitest forma

purified immunoglobulin

antitest terméktípus

primary antibodies

klón

DP3B3, monoclonal

form

buffered aqueous solution

molekulatömeg

antigen ~36 kDa

faj reaktivitás

rat, human, bovine, hamster, monkey, chicken, mouse, canine

technika/technikák

immunocytochemistry: suitable
immunoprecipitation (IP): suitable
microarray: suitable
western blot: 1-2 μg/mL using total cell extract from 293T cell line

izotípus

IgG2a

UniProt elérési szám

P22626

kiszállítva

dry ice

tárolási hőmérséklet

−20°C

célzott transzláció utáni módosítás

unmodified

Géninformáció

human ... HNRNPA2B1(3181)
mouse ... Hnrnpa2b1(53379)
rat ... Hnrnpa2b1(362361)

Általános leírás

Monoclonal Anti-hnRNP-A2/B1 (mouse IgG2a isotype) is derived from the DP3B3 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with recombinant human hnRNP-A2. hnRNP-A2/B1 proteins are located in the nucleus of most tissues cells. However, the hnRNP-A2 protein is found also in the cytoplasm of skin and esophagus cells. In rat brain, hnRNP-A2/B1 proteins are found in neurons in the cerebral cortices, hippocampal formation, olfactory regions, caudate-putamin and the supraoptic nucleus of the hypothalamus.

Immunogen

recombinant human hnRNP-A2.

Alkalmazás

Monoclonal Anti-hnRNP-A2/B1 antibody produced in mouse been used in :
  • enzyme linked immunosorbent assay (ELISA)
  • immunoblotting
  • immunoprecipitation
  • immunocytochemistry

Biokémiai/fiziológiai hatások

In cells, it actively participates in pre-messenger RNA (pre-mRNA) processing, mRNA metabolism and transportation. It is overexpressed in the initial stage of lung cancer and in premalignant lesions. It also participates in neurodegeneration mediated by rCGG (repeats).

Fizikai forma

Solution in 0.01 M phosphate buffered saline, pH 7.4, and 15 mM sodium azide.

Jogi nyilatkozat

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Tárolási osztály kódja

12 - Non Combustible Liquids

WGK

nwg

Lobbanási pont (F)

Not applicable

Lobbanási pont (C)

Not applicable

Analitikai tanúsítványok (COA)

Analitikai tanúsítványok (COA) keresése a termék sarzs-/tételszámának megadásával. A sarzs- és tételszámok a termék címkéjén találhatók, a „Lot” vagy „Batch” szavak után.

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Az Ön által nemrégiben megvásárolt termékekre vonatkozó dokumentumokat a Dokumentumtárban találja.

Dokumentumtár megtekintése

RNA-binding proteins hnRNP A2/B1 and CUGBP1 suppress fragile X CGG premutation repeat-induced neurodegeneration in a Drosophila model of FXTAS
Sofola OA, et al.
Neuron, 55(4), 565-571 (2007)
Immunohistochemical study of the hnRNP A2 and B1 in the rat forebrain
Mizukami K, et al.
Neuroreport, 11(14), 3099-3102 (2000)
Rocio Bengoechea et al.
Human molecular genetics, 24(23), 6588-6602 (2015-09-13)
Limb-girdle muscular dystrophy type 1D (LGMD1D) is caused by dominantly inherited missense mutations in DNAJB6, an Hsp40 co-chaperone. LGMD1D muscle has rimmed vacuoles and inclusion bodies containing DNAJB6, Z-disc proteins and TDP-43. DNAJB6 is expressed as two isoforms; DNAJB6a and
Nagalakshmi Nadiminty et al.
Molecular cancer therapeutics, 14(8), 1884-1895 (2015-06-10)
Castration-resistant prostate cancer (CRPC) remains dependent on androgen receptor (AR) signaling. Alternative splicing of the AR to generate constitutively active, ligand-independent variants is one of the principal mechanisms that promote the development of resistance to next-generation antiandrogens such as enzalutamide.
Takahiro Kishikawa et al.
Nature communications, 7, 13006-13006 (2016-09-27)
Highly repetitive tandem arrays at the centromeric and pericentromeric regions in chromosomes, previously considered silent, are actively transcribed, particularly in cancer. This aberrant expression occurs even in K-ras-mutated pancreatic intraepithelial neoplasia (PanIN) tissues, which are precancerous lesions. To examine the
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