P9297

Paromomycin sulfate salt

≥98% (TLC)

• Szinonimák: Aminosidine sulfate
• Tapasztalati képlet (Hill-képlet): C₂₃H₄₅N₅O₁₄ · xH₂SO₄
• CAS-szám: 1263-89-4
• Molekulatömeg: 615.63 (free base basis)
• Beilstein: 5715182
• UNSPSC kód: 51281663
• PubChem Substance ID: 24278662
• NACRES: NA.85

Tulajdonságok

• Minőségi szint: 200
• Teszt: ≥98% (TLC)
• Forma: powder
• antibiotikus hatásspektrum: Gram-negative bacteria; Gram-positive bacteria; parasites
• Hatásmechanizmus: protein synthesis | interferes
• SMILES string: O[C@H]1[C@H](O)[C@@H](CO)O[C@H](O[C@@]2([H])[C@H](O[C@@]3([H])[C@H](O)[C@H](O[C@]4([H])[C@H](N)[C@@H](O)[C@H](O)[C@H](CN)O4)[C@@H](CO)O3)[C@@H](O)[C@H](N)C[C@@H]2N)[C@@H]1N.C
• InChI: 1S/C23H45N5O14.CH4/c24-2-7-13(32)15(34)10(27)21(37-7)41-19-9(4-30)39-23(17(19)36)42-20-12(31)5(25)1-6(26)18(20)40-22-11(28)16(35)14(33)8(3-29)38-22;/h5-23,29-36H,1-4,24-28H2;1H4/t5-,6+,7+,8-,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+;/m1./s1
• Nemzetközi kémiai azonosító kulcs: OYJABWUHUYVDMJ-UDXJMMFXSA-N

Leírás

Általános leírás

Chemical structure: aminoglycoside

Alkalmazás

Paromomycin is a broad spectrum aminoglycoside antibiotic produced by Streptomyces rimosus var. paromomycinus. It has in vitro and in vivo activity similar to neomycin. It is effective against Gram-negative bacteria, Gram-positive bacteria, some protozoan species, and limited antihelminth.
It is used to study bacterial protein synthesis at the level of 16S ribosomal RNA and 30S ribosome assembly. Paromomycin is used to study cytosine-cytosine (CC) mismatch-containing RNA molecules and is used to inhibit Cryptosporidium infection of a human enterocyte cell line.

Biokémiai/fiziológiai hatások

Paromomycin inhibits the initiation and elongation steps of protein synthesis by binding to 16S ribosomal RNA. Paramomycin binds to the A site, which causes defective polypeptide chains to be produced and leads to cell death.

Kiszerelés

1g,5g,25g

Egyéb megjegyzések

Keep container tightly closed in a dry and well-ventilated place.

Biztonsági adatok

• Tárolási osztály kódja: 11 - Combustible Solids
• WGK: WGK 3
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable