P8953

Platelet-Derived Growth Factor from porcine platelets

≥97% (SDS-PAGE and N-terminal analysis), lyophilized powder, suitable for cell culture

• Szinonimák: PDGF
• MDL-szám: MFCD00166903
• UNSPSC kód: 12352202
• NACRES: NA.77

Tulajdonságok

• Terméknév: Platelet-Derived Growth Factor from porcine platelets, PDGF, lyophilized powder, suitable for cell culture
• biológiai forrás: Porcine
• Minőségi szint: 200
• Teszt: ≥97% (SDS-PAGE and N-terminal analysis)
• Forma: lyophilized powder
• hatékonyság: 39.00 ng/mL EC₅₀
• minőség: endotoxin tested
• molekulatömeg: glycoprotein 38 kDa
• kiszerelés: pkg of 5 μg
• tárolási körülmény: avoid repeated freeze/thaw cycles
• technika/technikák: cell culture | mammalian: suitable
• szennyeződések: ≤1 EU/μg
• szín: white
• UniProt elérési szám: P20034
• tárolási hőmérséklet: −20°C
• Géninformáció: pig ... PDGFB(100626465)

Leírás

Alkalmazás

PDGF elicits multifunctional actions with a variety of cells, including mitogenesis of mesoderm-derived cells, increased extracellular matrix synthesis, and chemotaxis and activation of neutrophils, monocytes and fibroblasts.

Biokémiai/fiziológiai hatások

The principal mitogen found in mammalian serum, released from platelets during clot formation. Elicits mitogenesis of mesoderm-derived cells, increased extracellular matrix synthesis, and chemotaxis and activation of neutrophils, monocytes and fibroblasts. Mitogenic for dermal and tendon fibroblasts, vascular smooth muscle cells, glial cells and chondrocytes. Appears to interact with transforming growth factor-β1 in accelerating wound healing. However, platelet-derived growth factor (PDGF) may also be pathogenic in arteriosclerosis and neoplasia.

Fizikai forma

Lyophilized from a 0.2 μm filtered solution in 40% acetonitrile and 0.1% trifluoroacetic acid, pH 2.0.

Analízis megjegyzés

The mitogenic activity is tested in culture using Swiss 3T3 cells or NR6-3T3 fibroblasts.

Biztonsági adatok

• Tárolási osztály kódja: 11 - Combustible Solids
• WGK: WGK 3
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable
• Egyéni védőeszköz: Eyeshields, Gloves, type N95 (US)