P8783

Progesterone

powder, BioReagent, suitable for cell culture

• Szinonimák: 4-Pregnene-3,20-dione
• Tapasztalati képlet (Hill-képlet): C₂₁H₃₀O₂
• CAS-szám: 57-83-0
• Molekulatömeg: 314.46
• Beilstein: 1915950
• EC-szám: 200-350-6
• MDL-szám: MFCD00003658
• UNSPSC kód: 12352209
• PubChem Substance ID: 24898978
• NACRES: NA.77

Tulajdonságok

• biológiai forrás: synthetic (organic)
• Minőségi szint: 200
• leírás: synthesized from materials derived from plant source
• termékcsalád: BioReagent
• Teszt: ≥99%
• form: powder
• hatékonyság: 0.1-20 ng/mL
• technika/technikák: cell culture | mammalian: suitable
• mp: 128-132 °C (lit.)
• oldhatóság: absolute ethanol: 1 mg/mL
• tárolási hőmérséklet: room temp
• SMILES string: CC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C
• InChI: 1S/C21H30O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12,16-19H,4-11H2,1-3H3/t16-,17+,18-,19-,20-,21+/m0/s1
• Nemzetközi kémiai azonosító kulcs: RJKFOVLPORLFTN-LEKSSAKUSA-N
• Géninformáció: human ... ABCB1(5243) , AR(367) , CYP2C9(1559) , EBP(10682) , ESR1(2099) , ESR2(2100) , NR3C1(2908) , NR3C2(4306) , PGR(5241) , SERPINA6(866) ; mouse ... Esr1(13982) ; rat ... Ar(24208) , Nr3c1(24413) , Pgr(25154)

Leírás

Általános leírás

Progesterone is a steroid hormone secreted by the ovaries.

Alkalmazás

Progesterone has been used:

• as a growth-promoting hormone in basal medium for bovine mammary epithelial cell culture
• to test its neuroprotective abilities in a well-characterized lateral cortical contusion injury (CCI) model
• as an endocytosis inhibitor to study its effect on Coxsackievirus A9 infection on A549 cells

Use in cell culture applications to study sterol regulation of cell signaling and gene expression.

Biokémiai/fiziológiai hatások

Induces maturation and secretory activity of the uterine endothelium; suppresses ovulation. Progesterone is implicated in the etiology of breast cancer.

Progesterone is a hormone that maintains pregnancy. It is essential for embryo formation, development and survival in almost all mammals. This hormone exhibits its action via progesterone receptor, which is specifically expressed in the endometrial stroma throughout pregnancy. It is known to prevent preterm delivery, when administered intramuscularly. Progesterone also controls gonadotropin secretion, activates sexual behavior and triggers ovarian events leading to ovulation. It stimulates the growth and differentiation of the uterus and prevents uterine contractility.

Egyéb megjegyzések

Steroid hormone produced by the corpus luteum.

Fizikai forma

powder-RT; stock-frozen in working aliquots, avoid repeated freeze/thaw

Feloldás

To prepare 20μg/ml stock solution, add 1ml absolute ethanol per mg progesterone, gently swirl to dissolve, add 49ml sterile medium per ml ethanol.

Biztonsági adatok

• Piktogramok: GHS08
• Figyelmeztetés: Danger
• Figyelmeztető mondatok: H351,H360FD,H362
• Óvintézkedésre vonatkozó mondatok: P202 - P260 - P263 - P264 - P280 - P308 + P313
• Veszélyességi osztályok: Carc. 2 - Lact. - Repr. 1A
• Tárolási osztály kódja: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable
• Egyéni védőeszköz: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges