O8264

Anti-ORAI1 antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution

• Szinonimák: Anti-CRACM1, Anti-Calcium release-activated calcium channel protein 1, Anti-TMEM142A, Anti-Transmembrane protein 142A
• UNSPSC kód: 12352203
• NACRES: NA.41
• konjugátum: unconjugated
• application: WB
• klón: polyclonal
• faj reaktivitás: human
• citations: 62
• technika/technikák: western blot: 1-2 μg/mL using whole extract of human HEK-293T cells expressing ORAI1

Tulajdonságok

• biológiai forrás: rabbit
• Minőségi szint: 200
• konjugátum: unconjugated
• antitest forma: affinity isolated antibody
• antitest terméktípus: primary antibodies
• klón: polyclonal
• Forma: buffered aqueous solution
• molekulatömeg: antigen ~35 kDa (non-glycosylated); antigen ~50 kDa (glycosylated)
• faj reaktivitás: human
• koncentráció: ~1.0 mg/mL
• technika/technikák: western blot: 1-2 μg/mL using whole extract of human HEK-293T cells expressing ORAI1
• UniProt elérési szám: Q96D31
• kiszállítva: dry ice
• tárolási hőmérséklet: −20°C
• célzott transzláció utáni módosítás: unmodified
• Géninformáció: human ... ORAI1(84876) ; mouse ... Orai1(109305)

Leírás

Általános leírás

ORAI calcium release-activated calcium modulator 1 (ORAI1) is the pore-forming subunit of the Ca²⁺ release-activated (CRAC) channel. The protein possesses four predicted transmembrane domains and intracellular amino and carboxyl-terminal domains. The ORAI1 gene is localized on human chromosome 12q24.31.

Immunogén

synthetic peptide corresponding to amino acids 288-301 of human ORAI1, conjugated to KLH. The corresponding sequence differs by 2 amino acids in rat and mouse.

Alkalmazás

Anti-ORAI1 antibody produced in rabbit has been used in immunohistochemistry and Western blotting.

Biokémiai/fiziológiai hatások

ORAI calcium release-activated calcium modulator 1 (ORAI1) modulates Ca²⁺ entry into cells. The channel is activated by stromal interaction molecule-1 (STIM-1). Mutation in the gene encoding the protein has been linked to late-onset tubular aggregate myopathy and congenital miosis.

Fizikai forma

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Jogi nyilatkozat

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Biztonsági adatok

• Tárolási osztály kódja: 10 - Combustible liquids
• WGK: WGK 3
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable
• Egyéni védőeszköz: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)