K1757

Keratinocyte Growth Factor human

≥95% (SDS-PAGE and HPLC), recombinant, expressed in E. coli, powder, suitable for cell culture

• Szinonimák: hFGF-7, hKGF, FGF-7, KGF
• CAS-szám: 148348-15-6
• MDL-szám: MFCD00212245
• UNSPSC kód: 12352202
• NACRES: NA.77

Tulajdonságok

• product name: Keratinocyte Growth Factor human, KGF, recombinant, expressed in E. coli, powder, suitable for cell culture
• biológiai forrás: human
• Minőségi szint: 200
• rekombináns: expressed in E. coli
• Teszt: ≥95% (SDS-PAGE and HPLC)
• form: powder
• hatékonyság: 0.1-15 ng/mL ED₅₀/EC₅₀
• minőség: endotoxin tested
• molekulatömeg: 18.9 kDa
• kiszerelés: pkg of 10 and 50 μg
• technika/technikák: cell culture | mammalian: suitable
• szennyeződések: 1 EU/μg
• UniProt elérési szám: P21781
• tárolási hőmérséklet: −20°C
• Géninformáció: human ... FGF7(2252)

Leírás

Általános leírás

Keratinocyte Growth Factor(KGF) is a 18.9 kDa growth factor, spanning 163 amino acids, belongs to the fibroblast growth factor family. It includes a secretory signal sequence and shares 39% identity with FGF-Basic. It is expressed in a number of stromal fibroblast cell lines, mesenchymal cells but absent from normal glial cells and epithelial cell lines.

Alkalmazás

Keratinocyte Growth Factor human has been used:

• as a component of epithelial growth medium
• as a positive control for antigen to determine the activity of the antibody
• to analyze the influence of KGF associated with thermo-sterilized carboxymethyl chitosan (NOCCts) in the reduction of pericardial adhesions

Biokémiai/fiziológiai hatások

Keratinocyte Growth Factor(KGF) stimulates proliferation and differentiation of keratinocytes and other cells in the epithelium. It induces chemotaxis of microvascular endothelial cells and neovascularization of rat cornea. It stimulates the hyaluronic acid synthesis in proliferating and migrating basal cells. KGF contributes to the survival of cells under stress conditions. KGF is highly expressed in injured and inflamed epithelial cells, thereby, promotes wound healing.

Fizikai forma

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 0.5 mg bovine serum albumin.

Analízis megjegyzés

Determined by a cell proliferation assay using 4MBr-5 cells.

Biztonsági adatok

• Tárolási osztály kódja: 11 - Combustible Solids
• WGK: WGK 3
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable
• Egyéni védőeszköz: dust mask type N95 (US), Eyeshields, Gloves