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G7422

Sigma-Aldrich

Anti-GSDMD (126-138) antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

Szinonimák:

Gasdermin D Antibody, Gasdermin D Antibody - Anti-GSDMD (126-138) antibody produced in rabbit, Gsdmd Antibody, Anti-DF5L, Anti-FKSG10, Anti-GSDMDC1, Anti-Gasdermin domain-containing protein 1

Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez
Összes fotó(4)

About This Item

UNSPSC kód:
12352203
NACRES:
NA.41

biológiai forrás

rabbit

Minőségi szint

200

konjugátum

unconjugated

antitest forma

IgG fraction of antiserum

antitest terméktípus

primary antibodies

klón

polyclonal

form

buffered aqueous solution

molekulatömeg

antigen ~55 kDa

faj reaktivitás

human

kiszerelés

antibody small pack of 25 μL

technika/technikák

immunoblotting: 1:250-1:500 using human HEK-293T cells over-expressing human recombinant. GSDMDC1.

UniProt elérési szám

P57764

alkalmazás(ok)

research pathology

kiszállítva

dry ice

tárolási hőmérséklet

−20°C

célzott transzláció utáni módosítás

unmodified

Géninformáció

human ... GSDMD(79792)

Általános leírás

Gasdermin D (GSDMD) is also known as DFNA5L or gasdermin domain-containing 1 (GSDMDC1), belongs to the gasdermin protein family of epithelial proliferation regulators. GSDMD is expressed in upper gastrointestinal epithelium differentiating cells.

Immunogen

synthetic peptide corresponding to amino acids 126-138 of human GSDMD

Alkalmazás

Anti-GSDMD (126-138) antibody produced in rabbit has been used in:
  • immunoblotting
  • CASP4/11 assay
  • cytokine enzyme?linked immunosorbent assay

Anti-GSDMD antibody produced in rabbit is suitable for western blot analysis at a working dilution of 1:500-1:2000.
Yale Center for High Throughput Cell Biology IF-tested antibodies. Each antibody is tested by immunofluorescence against HUVEC cells using the Yale HTCB IF protocol. To learn more about us and Yale Center for High Throughput Cell Biology partnership, visit sigma.com/htcb-if.

Biokémiai/fiziológiai hatások

GSDMD (gasdermin D) have been suggested to function in the regulation of epithelial apoptosis. GSDMD is expressed in differentiating cells. It may act as a tumor suppressor.
The absence of Gasdermin D (GSDMD), completely blocked LPS electroporation-triggered pyroptosis in studies performed on GSDMD siRNA knockdown or GSDMD knockout (both human HeLa cells and iBMDM mouse cells). It was also reported that caspase-4/11 specifically cleaves GSDMD after Asp275, results in gasdermin-N domain that bears intrinsic pyroptosis inducing activity. Furthermore, GSDMD-mediated pyroptosis participates in mature interleukin 1β (IL-1β) release without distressing its maturation.

Fizikai forma

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide

Jogi nyilatkozat

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Tárolási osztály kódja

10 - Combustible liquids

WGK

WGK 2

Lobbanási pont (F)

Not applicable

Lobbanási pont (C)

Not applicable

Egyéni védőeszköz

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Analitikai tanúsítványok (COA)

Analitikai tanúsítványok (COA) keresése a termék sarzs-/tételszámának megadásával. A sarzs- és tételszámok a termék címkéjén találhatók, a „Lot” vagy „Batch” szavak után.

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Az Ön által nemrégiben megvásárolt termékekre vonatkozó dokumentumokat a Dokumentumtárban találja.

Dokumentumtár megtekintése

Lan H Chu et al.
Nature communications, 9(1), 996-996 (2018-03-10)
Lipopolysaccharide (LPS) of Gram-negative bacteria can elicit a strong immune response. Although extracellular LPS is sensed by TLR4 at the cell surface and triggers a transcriptional response, cytosolic LPS binds and activates non-canonical inflammasome caspases, resulting in pyroptotic cell death
Mathias S Dick et al.
Nature communications, 7, 11929-11929 (2016-06-23)
A hallmark of inflammasome activation is the ASC speck, a micrometre-sized structure formed by the inflammasome adaptor protein ASC (apoptosis-associated speck-like protein containing a CARD), which consists of a pyrin domain (PYD) and a caspase recruitment domain (CARD). Here we
Elena Khanova et al.
Hepatology (Baltimore, Md.), 67(5), 1737-1753 (2017-11-07)
Alcoholic hepatitis (AH) continues to be a disease with high mortality and no efficacious medical treatment. Although severe AH is presented as acute on chronic liver failure, what underlies this transition from chronic alcoholic steatohepatitis (ASH) to AH is largely
Caspase-8 collaborates with caspase-11 to drive tissue damage and execution of endotoxic shock
Mandal P, et al.
Immunity, 49(1), 42-55 (2018)
Immune-complexed adenovirus induce AIM2-mediated pyroptosis in human dendritic cells
Eichholz K, et al.
PLoS Pathogens, 12(9), e1005871-e1005871 (2016)
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