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Merck
Összes fotó(1)

Fontos dokumentumok

G3046

Sigma-Aldrich

GDF-15 human

Szinonimák:

Growth differentiation factor 15, MIC-1, Macrophage inhibitory cyotkine-1

Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez
Összes fotó(1)

About This Item

CAS-szám:
1821355-80-9
UNSPSC kód:
12352202
NACRES:
NA.26

biológiai forrás

human

Minőségi szint

100

rekombináns

expressed in CHO cells

Teszt

>97% (visualized with silver stain, SDS-PAGE)

form

lyophilized powder

molekulatömeg

dimer 13 kDa (based on N-terminal sequencing, starting at the first histidine of the 6X histidine tag)

technika/technikák

cell culture | mammalian: suitable

szennyeződések

endotoxin, tested

UniProt elérési szám

Q99988

tárolási hőmérséklet

−20°C

Géninformáció

human ... GDF15(9518)

Általános leírás

Growth-differentiation factor-15 (GDF-15) is a stress-responsive member of the transforming growth factor-β cytokine superfamily. It is also known as PTGF-Growth-differentiation factor-15 (GDF-15) and is a stress-responsive member of the transforming growth factor-β cytokine superfamily.2 It is also known as PTGF-β, TGF-PL or MIC-1β, TGF-PL or MIC-1.

Alkalmazás

Growth-differentiation factor-15 (GDF-15) has been associated in the regulation of cell survival, proliferation, and differentiation and also in the protection from ischemia/reperfusion injury. Inflammatory and apoptotic pathways are regulated in injured tissues by GDFs during disease processes.

Biokémiai/fiziológiai hatások

Although it has been classified as a divergent member of the transforming growth factor-β superfamily, GDF-15 shares structural characteristics with this superfamily. It has been identified as a biomarker for human prostate cancer. Additionally, increased GDF-15 expression has been observed in breast, pancreas and colorectal cancers. Functions of this cytokine include inhibition of TNF-α production, initiation of cartilage formation, and promotion of neuronal survival.
It has been discussed to serve as a secreted biomarker for activation of the p53 pathway in human cancer.

Fizikai forma

Lyophilized from a 0.2 μm filtered solution in 30% acetonitrile, 0.1% trifluoroacetic acid containing 50 μg of bovine serum albumin per 1 μg of GDF-15.

Analízis megjegyzés

Under reducing conditions in SDS-PAGE, each recombinant GDF-15 monomer migrates as an ~14 kDa protein.

Tárolási osztály kódja

11 - Combustible Solids

WGK

WGK 3

Lobbanási pont (F)

Not applicable

Lobbanási pont (C)

Not applicable

Analitikai tanúsítványok (COA)

Analitikai tanúsítványok (COA) keresése a termék sarzs-/tételszámának megadásával. A sarzs- és tételszámok a termék címkéjén találhatók, a „Lot” vagy „Batch” szavak után.

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Dokumentumtár megtekintése

Renal failure and the histopathological features of myeloma kidney reversed by intensive chemotherapy and peritoneal dialysis.
P E Rose et al.
British medical journal (Clinical research ed.), 294(6569), 411-412 (1987-02-14)
K P Bland et al.
Quarterly journal of experimental physiology (Cambridge, England), 74(6), 813-824 (1989-11-01)
In order to examine whether an aspiration mechanism exists in the vomeronasal organ (VNO) of the domestic ram, experiments were conducted in chloralose-anaesthetized animals using acute electromanometry and electrophysiological techniques. Stimulation of the ipsilateral cervical sympathetic nerve activated a mechanism
Jennifer Lee et al.
PloS one, 10(6), e0131506-e0131506 (2015-06-27)
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Tudóscsoportunk valamennyi kutatási területen rendelkezik tapasztalattal, beleértve az élettudományt, az anyagtudományt, a kémiai szintézist, a kromatográfiát, az analitikát és még sok más területet.

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