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G0282

Sigma-Aldrich

Granulocyte-Macrophage Colony-Stimulating Factor from mouse

≥97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

Szinonimák:

GM-CSF

Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez
Összes fotó(2)

About This Item

MDL-szám:
MFCD00241918
UNSPSC kód:
12352202
NACRES:
NA.77

Terméknév

Granulocyte-Macrophage Colony-Stimulating Factor from mouse, GM-CSF, from mouse, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

biológiai forrás

mouse

Minőségi szint

200

rekombináns

expressed in E. coli

Teszt

≥97% (SDS-PAGE)

Forma

lyophilized powder

hatékonyság

≤0.2 ng/mL EC50 (corresponds to ≥5 × 106 units/mg)

minőség

endotoxin tested

molekulatömeg

~15 kDa (125 amino acids including N-terminal methionine)

kiszerelés

pkg of 5 and 50 μg

tárolási körülmény

avoid repeated freeze/thaw cycles

technika/technikák

cell culture | mammalian: suitable

szennyeződések

≤1 EU/mg

szín

white

oldhatóság

water: soluble, clear, colorless

UniProt elérési szám

P01587

tárolási hőmérséklet

−20°C

Géninformáció

mouse ... CSF2(12981) , Csf2(12981)

Related Categories

Biokémiai/fiziológiai hatások

Granulocyte-macrophage colony stimulating factor (GM-CSF) is a growth and differentiation factor for cells in the granulocyte, macrophage and eosinophil lineage. GM-CSF stimulates colony formation from pluripotential progenitor cells at extremely low concentrations and is an essential survival and proliferative factor for hematopoietic progenitor cells in all divisions up to maturity. It also stimulates growth in some epithelial cells and osteoclasts. GM-CSF is produced by a variety of cell types (monocytes, endothelial cells, T-cells, fibroblasts, mitogen-stimulated B-cells, and LPS-stimulated macrophages). GM-CSF is secreted as a single chain glycoprotein containing 128 amino acids for human with a conserved disulfide bond. Human and murine GM-CSF share approx. 54% sequence homology and do not cross-react in bioactivity.

Fizikai forma

Lyophilized from 10 mM acetic acid plus 250 μg BSA.

Analízis megjegyzés

The EC50 activity of mouse GM-CSF is tested in culture using murine FDP-1 cells.

Tárolási osztály kódja

11 - Combustible Solids

WGK

WGK 3

Lobbanási pont (F)

Not applicable

Lobbanási pont (C)

Not applicable

Egyéni védőeszköz

Eyeshields, Gloves, type N95 (US)

Válasszon a legfrissebb verziók közül:

Analitikai tanúsítványok (COA)

Lot/Batch Number
0000274734
0000181028
0000181027
028M4161V
028M4160V

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COA keresése

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Dokumentumtár megtekintése

M A Guthridge et al.
Stem cells (Dayton, Ohio), 16(5), 301-313 (1998-10-10)
The process of ligand binding leading to receptor activation is an ordered and sequential one. High-affinity binding of GM-CSF, interleukin 3 (IL-3), and IL-5 to their receptors induces a number of key events at the cell surface and within the
R C Skoda
Journal of receptor and signal transduction research, 19(1-4), 741-772 (1999-03-11)
The helical cytokines constitute a family of proteins with a common three-dimensional structure. They exert a wide variety of biological effects with a preference for the hematopoietic system. The effects of helical cytokines are mediated by cell surface receptors, which
M H Heim
Journal of receptor and signal transduction research, 19(1-4), 75-120 (1999-03-11)
The Jak-STAT pathway was originally discovered through the study of interferon induced intracellular signal transduction. Meanwhile, a large number of cytokines, hormones and growth factors have been found to activate Jaks and STATs. Jaks (Janus Kinases) are a unique class
Vasiliki Kyrargyri et al.
Glia, 63(4), 549-566 (2014-10-10)
Microglia are CNS resident immune cells and a rich source of neuroactive mediators, but their contribution to physiological brain processes such as synaptic plasticity, learning, and memory is not fully understood. In this study, we used mice with partial depletion
A Kelso
Immunology and cell biology, 76(4), 300-317 (1998-09-02)
Cytokines participate in the induction and effector phases of all immune and inflammatory responses. They are therefore obvious tools and targets for strategies designed to promote, inhibit or redirect these responses. However, the complexity of the cytokine network has hindered
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