H6916

Macrophage Colony-Stimulating Factor human

≥95% (SDS-PAGE), recombinant, expressed in HEK 293 cells, lyophilized powder, suitable for cell culture

• Szinonimák: MCSF
• MDL-szám: MFCD00166591
• UNSPSC kód: 12352202
• NACRES: NA.77

Tulajdonságok

• Terméknév: Macrophage Colony-Stimulating Factor human, M-CSF, recombinant, expressed in HEK 293 cells, suitable for cell culture
• biológiai forrás: human
• Minőségi szint: 100
• rekombináns: expressed in HEK 293 cells
• Teszt: ≥95% (SDS-PAGE)
• Forma: lyophilized powder
• hatékonyság: ≤4 ng/mL EC₅₀
• minőség: endotoxin tested
• molekulatömeg: dimer 35-40 kDa (glycosylated)
• kiszerelés: pkg of 10 μg
• gyártó/kereskedő neve: HumanZyme
• technika/technikák: cell culture | mammalian: suitable
• UniProt elérési szám: P09603
• tárolási hőmérséklet: −20°C
• Géninformáció: human ... CSF1(1435)

Leírás

Általános leírás

M-CSF is encoded by the gene mapped to human chromosome 1p13.3. It is a glycosylated polypeptide, which exists as a homodimer. M-CSF is produced by macrophage, fibroblasts, lymphocyte and endothelial cells.

Biokémiai/fiziológiai hatások

Macrophage CSF (M-CSF) as a growth factor, stimulates the proliferation and differentiation of monocyte/macrophage-lineage cells. It also boosts antibody-dependent, cell-mediated cytotoxicity by monocytes and macrophages. In addition, human M-CSF inhibits bone resorption by osteoclasts. It might also play a crucial role in atherosclerosis. Overexpression of the gene has been observed in Paget′s disease of bone (PDB).

Fizikai forma

Lyophilized from a 0.2 μm filtered solution of 1x PBS.

Analízis megjegyzés

The specific activity was determined by the dose-dependent stimulation of the proliferation of murine M-NFS-60 cells (mouse myeloid Leukemia indicator cell line).

Hivatkozás

1. Mazur, E.M., and Cohen, J.L., Clin. Pharmacol. Ther., 46, 250 (1989).
2. Morstyn, G., and Burgess, A.W., Cancer Res., 48, 5624 (1988).
3. Metcalf, D., Blood, 67, 257 (1986).
4. Mufson, R.A., et al., Cell. Immunol., 119, 182 (1989).
5. Hattersley, G., et al., J. Cell Physiol., 137, 199 (1988).

Jogi információk

HumanKine is a registered trademark of Proteintech Group, Inc. and Humanzyme, Inc

Biztonsági adatok

• Tárolási osztály kódja: 11 - Combustible Solids
• WGK: WGK 3
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable