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F3506

Sigma-Aldrich

N-Formyl-Met-Leu-Phe

≥97% (HPLC)

Szinonimák:

Chemotactic peptide, N-Formyl-L-methionyl-L-leucyl-L-phenylalanine, fMLF, fMLP (misnomer but widely used)

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Összes fotó(4)

About This Item

Tapasztalati képlet (Hill-képlet):
C21H31N3O5S
CAS-szám:
59880-97-6
Molekulatömeg:
437.55
Beilstein:
2315783
MDL-szám:
MFCD00036780
UNSPSC kód:
12352200
PubChem Substance ID:
24894846
NACRES:
NA.32

Minőségi szint

100

Teszt

≥97% (HPLC)

Forma

powder

molekulatömeg

437.55

tárolási körülmény

(Keep container tightly closed in a dry and well-ventilated place)

technika/technikák

activity assay: suitable

oldhatóság

acetic acid: 20 mg/mL, clear, colorless

tárolási hőmérséklet

−20°C

SMILES string

CSCC[C@H](NC=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(O)=O

InChI

1S/C21H31N3O5S/c1-14(2)11-17(23-19(26)16(22-13-25)9-10-30-3)20(27)24-18(21(28)29)12-15-7-5-4-6-8-15/h4-8,13-14,16-18H,9-12H2,1-3H3,(H,22,25)(H,23,26)(H,24,27)(H,28,29)/t16-,17-,18-/m0/s1

Nemzetközi kémiai azonosító kulcs

PRQROPMIIGLWRP-BZSNNMDCSA-N

Géninformáció

human ... FPR1(2357)

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Amino Acid Sequence

NFor-Met-Leu-Phe

Általános leírás

N-Formyl-Met-Leu-Phe is a chemotactic peptide, which functions on polymorphonuclear leukocytes (PMN), neutrophils etc.

Research area: Cell signaling

Alkalmazás

N-Formyl-Met-Leu-Phe has been used for:

  • creating gradients in Zigmond chamber chemotaxis assay performed on neutrophils
  • neutrophil chemotaxis assay
  • determination of the involvement of MAPK-activating protein kinase-2 (MAPKAPK-2) and/or p38, in the signaling pathway of human polymorphonuclear leukocytes (PMNs) stimulated by N-Formyl-Met-Leu-Phe.

Biokémiai/fiziológiai hatások

N-Formyl-Met-Leu-Phe induced chemotaxis in phosphoinositide 3-kinase γ (PI3K)γ-/- neutrophils, and promotes adhesion, polymerization of F-actin, Fcγ receptor-mediated phagocytosis and intracellular Ca2+ release. It acts as an inflammatory agent and activates polymorphonuclear leukocytes (PMNs) without the formation of 5-hydroxyicosatetraenoic acid (5-HETE) and leukotriene B4 (LTB4). Its effects on neutrophils and the inhibition of adenylate cyclase are inhibited by pertussis toxin.
Potent chemotactic peptide. Induces a metabolic burst in macrophages accompanied by an increase in respiratory rate, secretion of lysosomal enzymes, and production of superoxide anion.
Potent inducer of leucocyte chemotaxis and macrophage activator. Receptors that bind formylpeptides are found on phagocytic neutrophils and have recently been identified on cells of the intestinal mucosa.

antitest

Product No.
Leírás
Árazás

kapcsolódó termék

Product No.
Leírás
Árazás

Tárolási osztály kódja

11 - Combustible Solids

WGK

WGK 3

Lobbanási pont (F)

Not applicable

Lobbanási pont (C)

Not applicable

Egyéni védőeszköz

Eyeshields, Gloves, type N95 (US)

Válasszon a legfrissebb verziók közül:

Analitikai tanúsítványok (COA)

Lot/Batch Number
MKCX0763
MKCV7798
MKCS7331
MKCR6637
MKCS0024

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Pertussis toxin inhibits the N-formyl-Met-Leu-Phe (fMet-Leu-Phe) mediated human neutrophil functions of enzyme release, superoxide generation, aggregation, and chemotaxis. As pertussis toxin modifies the GTP binding receptor-regulatory protein "Ni," the association of the fMet-Leu-Phe receptor with such a protein was further
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