D9766

Dipyridamole

≥98% (HPLC), powder, phosphodiesterase V inhibitor

• Szinonimák: NSC 515776, NSC 619103
• Tapasztalati képlet (Hill-képlet): C₂₄H₄₀N₈O₄
• CAS-szám: 58-32-2
• Molekulatömeg: 504.63
• EC-szám: 200-374-7
• MDL-szám: MFCD00010555
• UNSPSC kód: 41106305
• PubChem Substance ID: 24277705
• NACRES: NA.77

Tulajdonságok

• Terméknév: Dipyridamole, ≥98% (HPLC)
• Minőségi szint: 200
• Teszt: ≥98% (HPLC)
• Forma: powder
• szín: yellow
• mp: 165-166 °C (lit.)
• oldhatóság: DMSO: soluble; ethanol: soluble
• kezdeményező: Boehringer Ingelheim
• tárolási hőmérséklet: room temp
• SMILES string: OCCN(CCO)c1nc(N2CCCCC2)c3nc(nc(N4CCCCC4)c3n1)N(CCO)CCO
• InChI: 1S/C24H40N8O4/c33-15-11-31(12-16-34)23-26-20-19(21(27-23)29-7-3-1-4-8-29)25-24(32(13-17-35)14-18-36)28-22(20)30-9-5-2-6-10-30/h33-36H,1-18H2
• Nemzetközi kémiai azonosító kulcs: IZEKFCXSFNUWAM-UHFFFAOYSA-N
• Géninformáció: human ... CYP1A2(1544) , PDE10A(10846) , PDE1A(5136) , PDE1B(5153) , PDE1C(5137) , PDE2A(5138) , PDE3A(5139) , PDE3B(5140) , PDE4A(5141) , PDE4B(5142) , PDE4C(5143) , PDE4D(5144) , PDE5A(8654) , PDE6A(5145) , PDE6B(5158) , PDE6C(5146) , PDE6D(5147) , PDE6G(5148) , PDE6H(5149) , PDE7A(5150) , PDE7B(27115) , PDE8A(5151) , PDE8B(8622) , PDE9A(5152) , SLC29A1(2030) ; mouse ... Slc29a1(63959)

Leírás

Általános leírás

Dipyridamole prevents cellular uptake of adenosine. It functions as an equilibrative nucleoside transporter 1 (ENT1) inhibitor.

Alkalmazás

Dipyridamole has been used:

• to perform in vitro growth inhibition assay(40)
• to determine its ability to prevent uterine myometrial contractions(41)
• to determine its effects on nicotinamide adenine dinucleotide (NAD+)-induced increase in intracellular adenosine triphosphate (ATP) levels(42)
• to prevent nicotinamide riboside (NR)-induced axonal protection(43)

Biokémiai/fiziológiai hatások

Selective inhibitor of phosphodiesterase V (PDE 5); potent coronary vasodilator drug; adenosine transport inhibitor; inhibitor of platelet aggregation.

Tulajdonságok és előnyök

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Phosphodiesterases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Boehringer Ingelheim. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Biztonsági adatok

• Tárolási osztály kódja: 11 - Combustible Solids
• WGK: WGK 2
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable
• Egyéni védőeszköz: dust mask type N95 (US), Eyeshields, Gloves