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Merck
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Fontos dokumentumok

C4585

Sigma-Aldrich

Anti-β-Tubulin−Cy3 antibody, Mouse monoclonal

clone TUB 2.1, purified from hybridoma cell culture

Szinonimák:

Monoclonal Anti-β-Tubulin

Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez
Összes fotó(1)

About This Item

UNSPSC kód:
12352203
NACRES:
NA.41

biológiai forrás

mouse

Minőségi szint

200

konjugátum

CY3 conjugate

antitest forma

purified from hybridoma cell culture

antitest terméktípus

primary antibodies

klón

TUB 2.1, monoclonal

form

buffered aqueous solution

molekulatömeg

antigen 55 kDa

faj reaktivitás

human, rat, frog, moth, mouse, plant, rabbit, chicken, bovine, wheat, sea urchin, hamster

tárolási körülmény

protect from light

technika/technikák

direct immunofluorescence: 1:100 using cultured chicken fibroblasts or BHK cells

izotípus

IgG1

kiszállítva

wet ice

tárolási hőmérséklet

2-8°C

célzott transzláció utáni módosítás

unmodified

Géninformáció

human ... TUBB(203068) , TUBB1(81027) , TUBB1(81027) , TUBB1(81027) , TUBB1(81027) , TUBB2A(7280) , TUBB2A(7280) , TUBB2A(7280) , TUBB2A(7280) , TUBB2C(10383) , TUBB2C(10383) , TUBB2C(10383) , TUBB2C(10383)
mouse ... Tubb1(104068) , Tubb1(104068) , Tubb1(104068) , Tubb1(104068) , Tubb2a(22151) , Tubb2a(22151) , Tubb2a(22151) , Tubb2a(22151) , Tubb2c(227613) , Tubb2c(227613) , Tubb2c(227613) , Tubb2c(227613) , Tubb3(22152)
rat ... Tubb2(29212) , Tubb2(29212) , Tubb2(29212) , Tubb2(29212) , Tubb2c(296554) , Tubb2c(296554) , Tubb2c(296554) , Tubb2c(296554)

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Általános leírás

Monoclonal Anti-b-Tubulin (mouse IgG1 isotype) is derived from the TUB2.1 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from mouse immunized with purified rat brain tubulin. Tubulin is the major building block of microtubules. This intracellular cylindrical filamentous structure is present in almost all eukaryotic cells. Tubulin is a heterodimer, which consists of α-tubulin and β-tubulin; both subunits have a molecular weight of 55 kDa and share considerable homology. β-tubulin structure is characterized with the core of two β-sheets enclosed by α-helices.

Egyediség

The antibody recognizes all five isoforms of β-tubulin (β1-β5). It reacts with the β-Lc and β-Sc fragments in the carboxy-terminal part of β−tubulin in immunoblotting. The antibody may be used to localize β−tubulin in cultured cells or tissue sections.

Immunogen

tubulin from rat brain.

Alkalmazás

Monoclonal Anti-β-Tubulin-Cy3 antibody produced in mouse has been used in:
  • immunohistochemical assays
  • immunofluorescence
  • western blotting
  • immunocytochemistry
  • immunoblotting
  • immunostaining

Biokémiai/fiziológiai hatások

Microtubules function as structural and mobile elements in mitosis, intracellular transport, flagellar movement and in the cytoskeleton. Mutation in the β-tubulin gene leads to various neuronal migration disorders such as lissencephaly, pachygyria and polymicrogyria malformations.

Fizikai forma

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide.

Jogi információk

Cy is distributed under license from Amersham Biosciences Limited.

Jogi nyilatkozat

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Tárolási osztály kódja

10 - Combustible liquids

WGK

nwg

Lobbanási pont (F)

Not applicable

Lobbanási pont (C)

Not applicable

Egyéni védőeszköz

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Analitikai tanúsítványok (COA)

Analitikai tanúsítványok (COA) keresése a termék sarzs-/tételszámának megadásával. A sarzs- és tételszámok a termék címkéjén találhatók, a „Lot” vagy „Batch” szavak után.

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Dokumentumtár megtekintése

Hong-Ryul Jung et al.
PloS one, 9(3), e91926-e91926 (2014-03-19)
Similar to stem cells, naïve T cells undergo asymmetric division following activation. While asymmetric division of T cells has been shown to be an important mechanism for the generation of lymphocyte fate diversity during immune responses, key factors that influence
Beta-and gamma-cytoplasmic actins are required for meiosis in mouse oocytes
Brockmann C, et al.
Biology of Reproduction, 85(5), 1025-1039 (2011)
Comprehensive genotype-phenotype correlation in lissencephaly
Tan AP, et al.
Quantitative imaging in medicine and surgery, 8(7), 673-673 (2018)
M Janmaleki et al.
Scientific reports, 6, 32418-32418 (2016-09-02)
This study focused on the effects of simulated microgravity (s-μg) on mechanical properties, major cytoskeleton biopolymers, and morphology of endothelial cells (ECs). The structural and functional integrity of ECs are vital to regulate vascular homeostasis and prevent atherosclerosis. Furthermore, these
MicroRNA-208a is a regulator of cardiac hypertrophy and conduction in mice
Callis TE, et al.
The Journal of Clinical Investigation, 119(9), 2772-2786 (2009)
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Cikkek

Antibodies to Tubulins, including Centrosome-Associated ε-Tubulin

Microtubules of the eukaryotic cytoskeleton are composed of a heterodimer of α- and β-tubulin. In addition to α-and β-tubulin, several other tubulins have been identified, bringing the number of distinct tubulin classes to seven.

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