C4042

Captopril

≥98% (HPLC), powder, angiotensin converting enzyme inhibitor

• Szinonimák: N-[(S)-3-Mercapto-2-methylpropionyl]-L-proline
• Tapasztalati képlet (Hill-képlet): C₉H₁₅NO₃S
• CAS-szám: 62571-86-2
• Molekulatömeg: 217.29
• Beilstein: 477887
• EC-szám: 263-607-1
• MDL-szám: MFCD00168073
• UNSPSC kód: 12352200
• PubChem Substance ID: 57654003
• NACRES: NA.77

Tulajdonságok

• Terméknév: Captopril, ≥98% (HPLC), powder
• biológiai forrás: synthetic
• Minőségi szint: 100
• Teszt: ≥98% (HPLC)
• Forma: powder
• szín: white to off-white
• mp: 104-108 °C (lit.)
• oldhatóság: water: 100 mg/mL, clear to very slightly hazy, colorless to faintly yellow
• kezdeményező: Bristol-Myers Squibb
• tárolási hőmérséklet: room temp
• SMILES string: C[C@H](CS)C(=O)N1CCC[C@H]1C(O)=O
• InChI: 1S/C9H15NO3S/c1-6(5-14)8(11)10-4-2-3-7(10)9(12)13/h6-7,14H,2-5H2,1H3,(H,12,13)/t6-,7+/m1/s1
• Nemzetközi kémiai azonosító kulcs: FAKRSMQSSFJEIM-RQJHMYQMSA-N
• Géninformáció: human ... ACE(1636) , AGTR1(185) , AGTR2(186) , ECE1(1889) ; rat ... Ace(24310)

Leírás

Alkalmazás

Captopril has been used:

• to examine the influence of timing of captopril treatment on efficacy in transverse aortic constriction (TAC) mice
• as an angiotensin-converting enzyme inhibitor and orally administered to unrestrained Wistar Kyoto rats in an approach to study its effects of angiogenesis inhibition and interdependency with other drugs
• used as a positive control in spectrophotometric assay to study the angiotensin-converting enzyme inhibitory activity

Biokémiai/fiziológiai hatások

Captopril is known to decrease the cardiovascular complications arising due to myocardial infarction. It is an effective drug in treating diabetic nephropathy and renal disease. Captopril acts by reducing cardiac related inflammation, fibrosis and calcification.

Angiotensin converting enzyme inhibitor. Inhibits the formation of angiotensin II, a bioactive peptide that stimulates angiogenesis and increases microvessel density.

Tulajdonságok és előnyök

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Neuropeptidases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Bristol-Myers Squibb. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Biztonsági adatok

• Piktogramok: GHS08
• Figyelmeztetés: Danger
• Figyelmeztető mondatok: H341,H360F
• Óvintézkedésre vonatkozó mondatok: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Veszélyességi osztályok: Muta. 2 - Repr. 1B
• Tárolási osztály kódja: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 2
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable
• Egyéni védőeszköz: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges