A3109

A-803467

≥98% (HPLC)

• Szinonimák: 5-4(-Chlorophenyl)-N-(3,5-dimethoxyphenyl)furan-2-carboxamide
• Tapasztalati képlet (Hill-képlet): C₁₉H₁₆NO₄Cl
• CAS-szám: 944261-79-4
• Molekulatömeg: 357.79
• MDL-szám: MFCD10574689
• UNSPSC kód: 12352200
• PubChem Substance ID: 329770815
• NACRES: NA.77

Tulajdonságok

• Minőségi szint: 100
• Teszt: ≥98% (HPLC)
• Forma: powder
• szín: white to tan
• oldhatóság: DMSO: >10 mg/mL
• kezdeményező: Abbott
• tárolási hőmérséklet: room temp
• SMILES string: COc1cc(NC(=O)c2ccc(o2)-c3ccc(Cl)cc3)cc(OC)c1
• InChI: 1S/C19H16ClNO4/c1-23-15-9-14(10-16(11-15)24-2)21-19(22)18-8-7-17(25-18)12-3-5-13(20)6-4-12/h3-11H,1-2H3,(H,21,22)
• Nemzetközi kémiai azonosító kulcs: VHKBTPQDHDSBSP-UHFFFAOYSA-N

Leírás

Általános leírás

A-803467 inhibits spontaneous and evoked action potentials in sensory neurons. It exhibits antinociceptive effects. A-803467 decreases the firing in spinal dorsal horn neurons in vivo.

The small molecule A-803467 is a potent and selective Nav1.8 sodium channel blocker. Nav1.8 is a tetrodotoxin-resistant (TTX-R) sodium channel that contributes to pain sensation by transmitting pain stimuli in peripheral sensory neurons; blockage of this channel by A-803467 reduces pain with varying effectiveness in a number of different models. A-803467 has been used to further understand the role of Nav1.8 in transmitting pain stimuli and also can be used as an analgesic.

Biokémiai/fiziológiai hatások

A-803467 blocks Nav1.8 in both half-maximal inactive and resting states with an IC₅₀ of 8 nM and IC₅₀ of 79 nM, respectively. A-803467 is over 100-fold more selective vs. human Nav1.2, 1.3, 1.5 and 1.7.

Tulajdonságok és előnyök

This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Biztonsági adatok

• Tárolási osztály kódja: 11 - Combustible Solids
• WGK: WGK 3
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable