165062K
MAPTRIX-C-DGEA
Collagen Mimetic, aqueous solution
Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez
Méret kiválasztása
2.5 MG
69 600,00 Ft
69 600,00 Ft
Az elérhetőséggel kapcsolatos kérdésekkel kérjük, forduljon Vevőszolgálatunkhoz.
Megrendelés igénylése nagy tételben
Összes fotó(1)
Méret kiválasztása
Nézet módosítása
2.5 MG
69 600,00 Ft
About This Item
UNSPSC kód:
12352202
NACRES:
NA.75
69 600,00 Ft
Az elérhetőséggel kapcsolatos kérdésekkel kérjük, forduljon Vevőszolgálatunkhoz.
Megrendelés igénylése nagy tételben
Javasolt termékek
biológiai forrás
synthetic
sterilitás
Filtered sterilized solution
Forma
aqueous solution
molekulatömeg
~23.0 kDa
kiszerelés
pkg of 2.5 mg
koncentráció
0.5 mg/mL protein
technika/technikák
cell culture | mammalian: suitable
Kötési specifikusság
Receptor: α2β1
Domain: α1(I)
Binding Motif: DGEA
kiszállítva
ambient
tárolási hőmérséklet
2-8°C
Alkalmazás
MAPTrix™ Technology provides a true extracellular microenvironment (ECM) by presenting combinatorial peptide motifs. The ECM, defined by biochemical cues and physical cues, is a deciding factor in a wide range of cellular processes including cell adhesion, proliferation, differentiation, and expression of phenotype-specific functions.Currently existing technology offers simple and merely adequate environments that facilitate simple cell processes such as cellular adhesion.[1][2] The simple presentation of cell adhesion motifs is not optimal for controlling more integrated processes. Crosstalk among signaling pathways act synergistically to enhance cellular responses such as cell adhesion or proliferation.[3] A study showed that a combination of extracellular matrix derived peptides presented on a surface may enhance cell adhesion strength and focal adhesion assembly. The combinatorial presentation of ECM peptides on cell growth surfaces may also promote elevated proliferation rates of primary or stem cells.[4][5][6]
Tulajdonságok és előnyök
- Biochemically-defined, animal-free cell culture surfaces designed to enhance cell performance
- MAPTrix™ produces a uniform ECM surface that provides a highly controlled 2D extracellular microenvironment for cell cultures and related applications
- Adhesion properties of the mussel adhesive protein makes the coating reproducible & reliable
Jogi információk
MAPTrix is a trademark of Kollodis Biosciences
Tárolási osztály kódja
10 - Combustible liquids
Lobbanási pont (F)
Not applicable
Lobbanási pont (C)
Not applicable
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Analitikai tanúsítványok (COA)
Lot/Batch Number
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Samuel Schmidt et al.
Cell and tissue research, 339(1), 83-92 (2009-11-19)
Adhesion and migration are integrated cell functions that build, maintain and remodel the multicellular organism. In migrating cells, integrins are the main transmembrane receptors that provide dynamic interactions between extracellular ligands and actin cytoskeleton and signalling machineries. In parallel to
Seung Tae Lee et al.
Biomaterials, 31(6), 1219-1226 (2009-11-21)
We present development and use of a 3D synthetic extracellular matrix (ECM) analog with integrin-specific adhesion ligands to characterize the microenvironmental influences in embryonic stem cell (ESC) self-renewal. Transcriptional analysis of 24 integrin subunits followed by confirmation at the translational
Stephanie J Ellis et al.
Cell and tissue research, 339(1), 121-130 (2009-07-10)
The regulation of stem cell behavior and maintenance typically involves the integration of both intrinsic and extrinsic cues. One such external cue, integrin-mediated cell adhesion to the extracellular matrix, plays an important part in regulating stem cell function and maintenance.
S J Fashena et al.
Nature cell biology, 2(12), E225-E229 (2001-01-09)
Over the past twenty years, intensive research has enabled us to identify components of specific signalling pathways downstream of an array of adhesion and growth-factor receptors. The first Gordon Research Conference on 'Signalling by Adhesion Receptors', which took place in
Catherine D Reyes et al.
Journal of cellular physiology, 217(2), 450-458 (2008-07-10)
Cell adhesion to extracellular matrix (ECM) components through cell-surface integrin receptors is essential to the formation, maintenance and repair of numerous tissues, and therefore represents a central theme in the design of bioactive materials that successfully interface with the body.
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