74601

3,3′-Diindolylmethane

analytical standard

• Szinonimák: 3,3′-Bisindolylmethane, DIM
• Tapasztalati képlet (Hill-képlet): C₁₇H₁₄N₂
• CAS-szám: 1968-05-4
• Molekulatömeg: 246.31
• MDL-szám: MFCD00195766
• UNSPSC kód: 41116107
• NACRES: NA.24

Tulajdonságok

• grade: analytical standard
• Minőségi szint: 100
• Teszt: ≥97.5% (HPLC)
• eltarthatósági idő: limited shelf life, expiry date on the label
• alkalmazás(ok): food and beverages
• Formátum: neat
• tárolási hőmérséklet: 2-8°C
• SMILES string: C(c1c[nH]c2ccccc12)c3c[nH]c4ccccc34
• InChI: 1S/C17H14N2/c1-3-7-16-14(5-1)12(10-18-16)9-13-11-19-17-8-4-2-6-15(13)17/h1-8,10-11,18-19H,9H2
• Nemzetközi kémiai azonosító kulcs: VFTRKSBEFQDZKX-UHFFFAOYSA-N

Leírás

Általános leírás

3,3′-Diindolylmethane, a dimer of indole-3-carbinol, is a component of cruciferous vegetables. It is known to exhibit anticancer effects.

Alkalmazás

3,3′-Diindolylmethane may be used as a model substrate to analyze the role of 3,3′-diindolylmethane in inducing apoptosis in human cancer cells.

Biokémiai/fiziológiai hatások

Acid-catalyzed reaction product of a phytochemical naturally found in Brassicaceae, indole-3-carbinol. It functions as an antitumor agent. This derivative can both directly stimulate apoptosis at relatively high concentrations and sensitize TRAIL-induced apoptosis in human cancer cells. DIM induces a G₁ cell cycle arrest in human breast cancer MCF-7 cells by a mechanism that includes increased expression of p21. DIM is a strong mitochondrial H⁺-ATPase inhibitor. The function of DIM and its derivatives as a new plant growth promoter has been studied in an eco-friendly system.

Javasolt termékek

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Biztonsági adatok

• Piktogramok: GHS07
• Figyelmeztetés: Warning
• Figyelmeztető mondatok: H315,H319,H335,H413
• Óvintézkedésre vonatkozó mondatok: P273 - P302 + P352 - P305 + P351 + P338
• Veszélyességi osztályok: Aquatic Chronic 4 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Célzott szervek: Respiratory system
• Tárolási osztály kódja: 11 - Combustible Solids
• WGK: WGK 3
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable