MAB1987Z
Anti-Integrin β1 Antibody, clone P4C10, azide free
clone P4C10, Chemicon®, from mouse
Szinonimák:
CD29, MAB1987
Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez
Összes fotó(1)
About This Item
UNSPSC kód:
12352203
eCl@ss:
32160702
NACRES:
NA.41
klón:
P4C10, monoclonal
application:
ELISA
ICC
IP
WB
ICC
IP
WB
faj reaktivitás:
human
technika/technikák:
ELISA: suitable
immunocytochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable
immunocytochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable
citations:
24
Javasolt termékek
biológiai forrás
mouse
Minőségi szint
antitest forma
purified immunoglobulin
antitest terméktípus
primary antibodies
klón
P4C10, monoclonal
faj reaktivitás
human
gyártó/kereskedő neve
Chemicon®
technika/technikák
ELISA: suitable
immunocytochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable
izotípus
IgG2a
NCBI elérési szám
UniProt elérési szám
kiszállítva
wet ice
célzott transzláció utáni módosítás
unmodified
Géninformáció
human ... ITGB1(3688)
Általános leírás
Integrin beta 1, also known as CD29, is a 130 kDa transmembrane glycoprotein that forms noncovalent complexes with various Integrin alpha subunits (including alpha 1, alpha 2, alpha 3, alpha 4, alpha 5, and alpha 6) to form the functional receptors that bind to specific extracellular matrix proteins. Integrin receptors are involved in the regulation of a variety of important biological functions, including embryonic development, wound repair, hemostasis, and prevention of programmed cell death. They are also implicated in abnormal pathological states such as tumor directed angiogenesis, tumor cell growth, and metastasis. These heterodimeric receptors bridge the cytoplasmic actin cytoskeleton with proteins present in the extracellular matrix and/or on adjacent cells. Interactions between integrins and the extracellular matrix lead to activation of signal transduction pathways and regulation of gene expression.
Egyediség
Reacts with the beta-1 subunit of the integrin protein family. Appears to be human specific.Unlike many beta-1 monoclonals 4C10′s epitope is not trypsin sensitive.
Alkalmazás
Anti-Integrin β1 Antibody, clone P4C10, azide free detects level of Integrin β1 & has been published & validated for use in ELISA, IC, IP, FUNC & WB.
Inhibits attachment of UCLA-P3 cells to collagen type I (Wayner, 1991). Inhibits endodermal and keratinocytes to collagen, fibronectin and laminin. It also inhibits cell to cell adhesion. Typical dilution ranges are 1:50-1:500.
Immunoflourescence
Immunoblotting
Immunoprecipitation
ELISA
Immunocytochemistry Analysis: A 1:100 dilution from a representative lot detected Integrin β1 in HeLa cells.
Optimal working dilutions must be determined by end user.
Immunoflourescence
Immunoblotting
Immunoprecipitation
ELISA
Immunocytochemistry Analysis: A 1:100 dilution from a representative lot detected Integrin β1 in HeLa cells.
Optimal working dilutions must be determined by end user.
Research Category
Cell Structure
Cell Structure
Research Sub Category
Integrins
Integrins
Cél megnevezése
88 KDa
Kapcsolódás
Replaces: 04-1109
Fizikai forma
Format: Purified
Protein A Purified mouse immunoglobulin in 20 mM sodium phosphate, 250 mM NaCl, pH. 7.6, with no preservatives.
Protein A purified
Tárolás és stabilitás
Maintain for 1 year at 2–8°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Analízis megjegyzés
Control
Human Tonsil, human skin, human lung, liver, and skeletal muscle tissues
Human Tonsil, human skin, human lung, liver, and skeletal muscle tissues
Egyéb megjegyzések
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Jogi információk
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Jogi nyilatkozat
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Próbálja ki a Termékválasztó eszköz. eszközt
javasolt
Tárolási osztály kódja
12 - Non Combustible Liquids
WGK
WGK 2
Lobbanási pont (F)
Not applicable
Lobbanási pont (C)
Not applicable
Analitikai tanúsítványok (COA)
Analitikai tanúsítványok (COA) keresése a termék sarzs-/tételszámának megadásával. A sarzs- és tételszámok a termék címkéjén találhatók, a „Lot” vagy „Batch” szavak után.
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Az Ön által nemrégiben megvásárolt termékekre vonatkozó dokumentumokat a Dokumentumtárban találja.
Steven Mortillo et al.
The Journal of comparative neurology, 520(9), 2041-2052 (2012-04-11)
β1-containing integrins are required for persistent synaptic potentiation in hippocampus and regulate hippocampal-dependent learning. Based largely on indirect evidence, there is a prevailing assumption that β1-integrins are localized at synapses, where they contribute to synapse adhesion and signaling, but this
Geneviève Dufour et al.
The Journal of biological chemistry, 279(42), 44113-44122 (2004-08-10)
We have shown previously that human intestinal epithelial cell survival and anoikis are distinctively regulated according to the state of differentiation. Here we analyzed the roles of protein kinase B/Akt isoforms in such differentiation state distinctions. Anoikis was induced in
Thomas Kaido et al.
Diabetes, 55(10), 2723-2729 (2006-09-28)
The impact of extracellular matrix on insulin production needs to be understood both to optimize the derivation of functional beta-cells for transplantation and to understand mechanisms controlling islet neogenesis and glucose homeostasis. In this study, we present evidence that adhesion
Integrin-driven actin polymerization consolidates long-term potentiation.
Kramar, EA; Lin, B; Rex, CS; Gall, CM; Lynch, G
Proceedings of the National Academy of Sciences of the USA null
Integrin dynamics produce a delayed stage of long-term potentiation and memory consolidation.
Babayan, AH; Kramar, EA; Barrett, RM; Jafari, M; Haettig, J; Chen, LY; Rex et al.
The Journal of Neuroscience null
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