691550-M

Zinc (II) Protoporphyrin IX

A potent and selective inhibitor of heme oxygenase, the enzyme which generates carbon monoxide (CO) and biliverdin.

• Szinonimák: Zinc (II) Protoporphyrin IX, ZnPP-9
• Tapasztalati képlet (Hill-képlet): C₃₄H₃₂N₄O₄Zn
• CAS-szám: 15442-64-5
• Molekulatömeg: 626.03
• MDL-szám: MFCD00011612
• UNSPSC kód: 12171500
• NACRES: NA.22

Tulajdonságok

• Minőségi szint: 100
• Teszt: ≥95% (TLC)
• Forma: solid
• gyártó/kereskedő neve: Calbiochem^®
• tárolási körülmény: OK to freeze; protect from light
• szín: dark red
• oldhatóság: DMF: soluble; pyridine: soluble
• tárolási hőmérséklet: −20°C
• SMILES string: [Zn+2].[n-]1c2cc3nc(cc4[n-]c(cc5nc(cc1c(c2CCC(=O)O)C)c(c5C=C)C)c(c4C=C)C)c(c3CCC(=O)O)C
• InChI: 1S/C34H34N4O4.Zn/c1-7-21-17(3)25-13-26-19(5)23(9-11-33(39)40)31(37-26)16-32-24(10-12-34(41)42)20(6)28(38-32)15-30-22(8-2)18(4)27(36-30)14-29(21)35-25;/h7-8,13-16H,1-2,9-12H2,3-6H3,(H4,35,36,37,38,39,40,41,42);/q;+2/p-2/b25-13?,26-13-,27-14?,28-15-,29-14-,30-15?,31-16-,32-16?;
• Nemzetközi kémiai azonosító kulcs: FUTVBRXUIKZACV-RGUWPKJZSA-L

Leírás

Általános leírás

A potent and selective inhibitor of heme oxygenase, the enzyme which generates carbon monoxide (CO) and biliverdin. Inhibits soluble guanylyl cyclase and produces a time- and concentration-dependent inactivation of all three isoforms of nitric oxide synthase (IC₅₀ = 800 nM, 4 µM, and 5 µM for nNOS, iNOS, and eNOS, respectively). Inhibits relaxation induced by acetylcholine, ANP, and VIP in isolated rat aorta. Blocks interleukin-1 and prevents induction of long-term potentiation. Also useful as an indicator of iron-deficient erythropoiesis. Does not cross the blood-brain barrier.

A potent and selective inhibitor of heme oxygenase, the enzyme which generates carbon monoxide (CO) and biliverdin. Inhibits soluble guanylyl cyclase. Produces a time- and concentration-dependent inactivation of all three isoforms of nitric oxide synthase (IC₅₀ = 0.8 µM, 4.0 µM, and 5.0 µM for nNOS, iNOS, and eNOS, respectively). Inhibits relaxation induced by acetylcholine, ANP, and VIP in isolated rat aorta. Blocks interleukin-1 and prevents induction of long-term potentiation. Also useful as an indicator of iron deficient erythropoiesis. Does not cross the blood-brain barrier.

Biokémiai/fiziológiai hatások

Primary Target
heme oxygenase

Target IC₅₀: 800 nM, 4 µM, and 5 µM for nNOS, iNOS, and eNOS, respectively

Figyelmeztetés

Toxicity: Standard Handling (A)

Egyéb megjegyzések

Wolff, D.J., et al. 1996. Arch. Biochem. Biophys.333, 27.
Bing, O., et al. 1995. NeuroReport 6, 1369.
Hinchliffe, R.F., et al. 1995. Pediatr. Hematol. Oncol. 12, 455.
Kadoya, C., et al. 1995. Stroke 26, 1035.
Ny, L., et al. 1995. Br. J. Pharmacol. 115, 186.
Luo, D., and Vincent, S.R. 1994. Eur. J. Pharmacol. 267, 263.
Marks, G.S., et al. 1993. Can. J. Physiol. Pharmacol. 71, 753.
Zhuo, M., et al. 1993. Science 260, 1946.

Jogi információk

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Biztonsági adatok

• Tárolási osztály kódja: 11 - Combustible Solids
• WGK: WGK 3
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable