647925
Trichostatin A
from Streptomyces sp., ≥98% (HPLC), lyophilized solid, HDAC inhibitor, Calbiochem®
Szinonimák:
Trichostatin A, Streptomyces sp., 4,6-Dimethyl-7-[ p-dimethylaminophenyl]-7-oxahepta-2,4-dienohydroxamic Acid, TSA, HDAC Inhibitor IX
Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez
Összes fotó(1)
About This Item
Tapasztalati képlet (Hill-képlet):
C17H22N2O3
CAS-szám:
Molekulatömeg:
302.37
MDL-szám:
UNSPSC kód:
12352200
NACRES:
NA.77
Javasolt termékek
Terméknév
Trichostatin A, Streptomyces sp., A potent and reversible, cell-permeable inhibitor of histone deacetylase.
Minőségi szint
Teszt
≥98% (HPLC)
Forma
lyophilized solid
gyártó/kereskedő neve
Calbiochem®
tárolási körülmény
OK to freeze
szín
off-white
oldhatóság
ethanol: 1 mg/mL
DMSO: 20 mg/mL
methanol: soluble
kiszállítva
ambient
tárolási hőmérséklet
−20°C
SMILES string
N(O)C(=O)\C=C\C(=C\C(C)C(=O)c1ccc(cc1)N(C)C)\C
InChI
1S/C17H22N2O3/c1-12(5-10-16(20)18-22)11-13(2)17(21)14-6-8-15(9-7-14)19(3)4/h5-11,13,22H,1-4H3,(H,18,20)/b10-5+,12-11+
Nemzetközi kémiai azonosító kulcs
RTKIYFITIVXBLE-WKWSCTOISA-N
Általános leírás
A potent and reversible inhibitor of histone deacetylase. Blocks cell cycle progression at the G1 phase in HeLa cells and induces a 12-fold increase in intracellular levels of gelsolin. Induces reversion of oncogenic ras-tranformed NIH 3T3 cells to a normal morphology. Inhibits IL-2 gene expression (IC50 = 73 nM) in Jurkat cells and shows immunosuppressive activity in a mouse model. IC50 = 6 nM for HDAC1; 38 nM for HDAC4, and 8.6 nM for HDAC6A.
A potent and reversible, cell-permeable inhibitor of histone deacetylase. Blocks cell cycle progression at the G1 phase in HeLa cells and induces a 12-fold increase in intracellular levels of gelsolin. Induces reversion of oncogenic ras-transformed NIH/3T3 cells to a normal morphology. Inhibits IL-2 gene expression (IC50 = 73 nM) in Jurkat cells and shows immunosuppressive activity in a mouse model. Down-regulates p57kip2 in Hep 3Bcells. IC50 = 6 nM for HDAC1; 38 nM for HDAC4, and 8.6 nM for HDAC6A. 10 mM (500 µg/165 µl) solution of Trichostatin A, Streptomyces sp. (Cat. No. 647926) in DMSO is also available.
Biokémiai/fiziológiai hatások
Cell permeable: yes
Primary Target
histone deactylase
histone deactylase
Product does not compete with ATP.
Reversible: yes
Target IC50: 73 nM inhibiting IL-2 gene expressionin Jurkat cells
Figyelmeztetés
Toxicity: Harmful (C)
Feloldás
Following reconstitution in DMSO, aliquot and freeze (-20°C). Following reconstitution in ethanol, refrigerate (4°C). DMSO stock solutions are stable for up to 6 months at -20°C. Ethanol stock solutions are stable for up to 3 months at 4°C.
Egyéb megjegyzések
Furumai, R., et al. 2001. Proc. Natl. Acad. Sci. USA98, 87.
Gray, S.G. and Ekstrom, T.J. 1998. Biochem. Biophys. Res. Commun. 245, 423.
Takahashi, I., et al. 1996. J. Antibiot. 49, 453.
Taunton, J., et al. 1996. Science 272, 408.
Futamura, M., et al. 1995. Oncogene 10, 1119.
Hoshikawa, Y., et al. 1994. Exp. Cell Res. 214, 189.
Gray, S.G. and Ekstrom, T.J. 1998. Biochem. Biophys. Res. Commun. 245, 423.
Takahashi, I., et al. 1996. J. Antibiot. 49, 453.
Taunton, J., et al. 1996. Science 272, 408.
Futamura, M., et al. 1995. Oncogene 10, 1119.
Hoshikawa, Y., et al. 1994. Exp. Cell Res. 214, 189.
Jogi információk
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Tárolási osztály kódja
10 - Combustible liquids
WGK
WGK 3
Analitikai tanúsítványok (COA)
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