233165

Clioquinol

A metal ion chelator that crosses the blood brain barrier and acts as a neurotoxic antibiotic.

• Szinonimák: Clioquinol, 5-Chloro-7-iodo-8-hydroxyquinoline
• Tapasztalati képlet (Hill-képlet): C₉H₅ClINO
• CAS-szám: 130-26-7
• Molekulatömeg: 305.50
• MDL-szám: MFCD00006787
• UNSPSC kód: 12352200
• NACRES: NA.77

Tulajdonságok

• Minőségi szint: 100
• Teszt: ≥95% (HPLC)
• form: solid
• gyártó/kereskedő neve: Calbiochem^®
• tárolási körülmény: OK to freeze; protect from light
• oldhatóság: ethanol: 1 mg/mL; methanol: 1.5 mg/mL; DMSO: 20 mg/mL
• kiszállítva: ambient
• tárolási hőmérséklet: −20°C
• InChI: 1S/C9H5ClINO/c10-6-4-7(11)9(13)8-5(6)2-1-3-12-8/h1-4,13H
• Nemzetközi kémiai azonosító kulcs: QCDFBFJGMNKBDO-UHFFFAOYSA-N

Leírás

Általános leírás

A metal ion chelator that crosses the blood brain barrier and acts as a neurotoxic antibiotic. Reported to dissolve senile plaques and reduce amyloid’s ability to clump together, apparently by trapping the Cu²⁺ and Zn²⁺ that stud these deposits. Shown to increase distal dominant axonopathy in animal models.

A metal ion chelator that crosses the blood-brain barrier and acts as a neurotoxic antibiotic. Reported to dissolve senile plaques and reduce amyloid′s ability to clump together, apparently by trapping the Cu²⁺ and Zn²⁺ that reduces the build-up of these deposits. Exhibits greater affinity for Cu²⁺ and Zn²⁺ than for Ca²⁺ and Mg²⁺. Shown to induce distal dominant axonopathy in animal models. Clioquinol treatment has been shown to be beneficial in a mouse model of Alzheimer′s disease.

Biokémiai/fiziológiai hatások

Cell permeable: no

Primary Target
Metal ion chelator

Product does not compete with ATP.

Reversible: no

Kiszerelés

Packaged under inert gas

Figyelmeztetés

Toxicity: Toxic & Carcinogenic / Teratogenic (G)

Feloldás

Following reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.

Egyéb megjegyzések

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Melov, S. 2002. Trends Neurosci.25, 121.
Regland, B., et al. 2001. Dement. Geriatr. Cogn. Disord.12, 408.
Helmuth, L., et al. 2000. Science290, 1273.
Tateishi, J., et al. 2000. Neuropathology20, Suppl: S20-4.

Jogi információk

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Biztonsági adatok

• Piktogramok: GHS06
• Figyelmeztetés: Danger
• Figyelmeztető mondatok: H301,H315,H317,H319
• Óvintézkedésre vonatkozó mondatok: P261 - P264 - P280 - P301 + P310 - P302 + P352 - P305 + P351 + P338
• Veszélyességi osztályok: Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1
• Tárolási osztály kódja: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3