204883

Complement C1-Esterase Inhibitor, Human

Complement C1-Esterase Inhibitor, Human, is a native, single-chain glycoprotein that is involved in regulation of complement, coagulation, fibrinolytic and contact systems of circulating plasma.

• UNSPSC kód: 12352202
• NACRES: NA.25

Tulajdonságok

• Minőségi szint: 100
• Teszt: ≥90% (SDS-PAGE)
• form: liquid
• nem tartalmaz: preservative
• gyártó/kereskedő neve: Calbiochem^®
• tárolási körülmény: OK to freeze; avoid repeated freeze/thaw cycles
• szennyeződések: IgG, IgA, IgM, albumin, C3, C4, or ceruloplasmin, trace
• kiszállítva: wet ice
• tárolási hőmérséklet: −70°C

Leírás

Általános leírás

Native, human C1-esterase. Complent C1-esterase inhibitor purified from human plasma. Single chain glycoprotein present in normal human serum at a concentration of 180 µg/ml. Involved in regulation of complement, coagulation, fibrinolytic and contact (kinin-forming) systems of circulating blood plasma. It is the only known inhibitor of activated C1r and C1s complement enzymes. Persons with either hereditary or acquired deficiencies of C1 esterase inhibitor are susceptible to recurrent attacks of angioedema.

Native, human C1-esterase. Single-chain glycoprotein present in normal human serum at 180 µg/ml. Involved in regulation of complement, coagulation, fibrinolytic and contact (kinin-forming) systems of circulating blood plasma. The only known inhibitor of activated C1r and C1s complement enzymes. The presence of either hereditary or acquired deficiencies of C1 inhibitor produce susceptibility to recurrent attacks of angioedema.

Biokémiai/fiziológiai hatások

≥80% of C1-esterase inhibitor will bind activated C1s.

Kiszerelés

Please refer to vial label for lot-specific concentration.

Figyelmeztetés

Toxicity: Standard Handling (A)

Fizikai forma

In PBS, pH 7.4, sterile-filtered through a 0.22 µm filter.

Elkészítési megjegyzés

Prepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.

Feloldás

Following initial thaw, aliquot and freeze (-70°C).

Egyéb megjegyzések

Bowen, B., et al. 2001. Clin. Immunol.98, 157.
Davis, A.E. 1988. Ann. Rev. Immunol. 6, 595.

Variables associated with assay conditions will dictate the proper working dilution.

Jogi információk

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Biztonsági adatok

• Tárolási osztály kódja: 10 - Combustible liquids
• WGK: WGK 1
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable