196322

Baicalein

A cell-permeable flavone that inhibits the activity of 12-lipoxygenase (IC₅₀= 120 nM) and reverse transcriptase.

• Szinonimák: Baicalein, 5,6,7-Trihydroxyflavone
• Tapasztalati képlet (Hill-képlet): C₁₅H₁₀O₅
• CAS-szám: 491-67-8
• Molekulatömeg: 270.24
• MDL-szám: MFCD00017459
• UNSPSC kód: 12352200
• NACRES: NA.77

Tulajdonságok

• Minőségi szint: 100
• Teszt: ≥98% (HPLC)
• form: solid
• gyártó/kereskedő neve: Calbiochem^®
• tárolási körülmény: OK to freeze
• szín: yellow
• oldhatóság: DMSO: 20 mg/mL; acetone: soluble
• kiszállítva: wet ice
• tárolási hőmérséklet: −20°C
• InChI: 1S/C15H10O5/c16-9-6-11(8-4-2-1-3-5-8)20-12-7-10(17)14(18)15(19)13(9)12/h1-7,17-19H
• Nemzetközi kémiai azonosító kulcs: FXNFHKRTJBSTCS-UHFFFAOYSA-N

Leírás

Általános leírás

A cell-permeable flavone that inhibits the activity of 12-lipoxygenase (IC₅₀ = 120 nM) and reverse transcriptase. Protects cortical neurons from β-amyloid induced toxicity. Reduces leukotriene biosynthesis and inhibits the release of lysosomal enzymes. Also inhibits cellular Ca²⁺ uptake and mobilization, and adjuvant-induced arthritis. Reported to inhibit microsomal lipid peroxidation by forming an iron-baicalein complex. Inhibits topoisomerase II and induces cell death in hepatocellular carcinoma cell lines. Potentiates contractile responses to nerve stimulation. Inhibits protein tyrosine kinase and PMA-stimulated protein kinase C.

A cell-permeable flavone that inhibits the activity of 12-lipoxygenase (IC₅₀ = 120 nM) and reverse transcriptase. Reduces leukotriene biosynthesis and the release of lysosomal enzymes. Also inhibits cellular Ca²⁺ uptake and mobilization, and adjuvant-induces arthritis. Potentiates contractile responses to nerve stimulation. Inhibits protein tyrosine kinase and PMA-stimulated PKC.

Biokémiai/fiziológiai hatások

Cell permeable: yes

Primary Target
12-lipoxygenase

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 120 nM against 12-lipoxygenase

Figyelmeztetés

Toxicity: Irritant (B)

Feloldás

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

Egyéb megjegyzések

Leabeau, A., et al. 2001. Neuroreport12, 2199.
Gao, D., et al. 1996. Biochem. Mol. Biol. Int. 39, 215.
Matsuzaki, Y., et al. 1996. Jpn. J. Cancer Res. 87, 170.
Huang, H.C., et al. 1994. Eur. J. Pharmacol. 268, 73.
Butenko, I.G., et al. 1993. Agents Actions 39, C49.
Abe, K., et al. 1990. Chem. Pharm. Bull.38, 209.
Kimura, Y., et al. 1987. Biochim. Biophys. Acta922, 278.
Sekiya, K., and Okuda, H. 1982. Biochem. Biophys. Res. Commun.105, 1090.

Jogi információk

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Biztonsági adatok

• Tárolási osztály kódja: 11 - Combustible Solids
• WGK: WGK 3
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable