104550

ACA

A cell-permeable inhibitor of phospholipase A2 that blocks epinephrine-stimulated thromboxane production in platelets.

• Szinonimák: ACA, N-( p-Amylcinnamoyl)anthranilic Acid, N-(p-Amylcinnamoyl)anthranilic Acid
• Tapasztalati képlet (Hill-képlet): C₂₁H₂₃NO₃
• CAS-szám: 110683-10-8
• Molekulatömeg: 337.41
• MDL-szám: MFCD00211365
• UNSPSC kód: 51111800
• NACRES: NA.77

Tulajdonságok

• Minőségi szint: 100
• Teszt: ≥99% (HPLC)
• Forma: solid
• gyártó/kereskedő neve: Calbiochem^®
• tárolási körülmény: OK to freeze; protect from light
• szín: white
• oldhatóság: ethanol: 10 mg/mL; DMSO: 50 mg/mL
• kiszállítva: ambient
• tárolási hőmérséklet: 10-30°C
• SMILES string: N(c2c(cccc2)C(=O)O)C(=O)\C=C\c1ccc(cc1)CCCCC
• InChI: 1S/C21H23NO3/c1-2-3-4-7-16-10-12-17(13-11-16)14-15-20(23)22-19-9-6-5-8-18(19)21(24)25/h5-6,8-15H,2-4,7H2,1H3,(H,22,23)(H,24,25)/b15-14+
• Nemzetközi kémiai azonosító kulcs: GAMRBCZMOOMBSQ-CCEZHUSRSA-N

Leírás

Általános leírás

A cell-permeable inhibitor of phospholipase A₂ that blocks epinephrine-stimulated thromboxane production in platelets. Inhibits ATP-stimulated phosphatidylcholine (PC) secretion in alveolar type II cells. Also blocks phorbol ester and A23187-induced PC secretion in type II cells. Reported to block glucose-induced insulin secretion by pancreatic β-cells. Exhibits moderate leukotriene antagonist activity.

Inhibits epinephrine-stimulated thromboxane production (86% at 3.5 μM) via inhibition of phospholipase A₂ (PLA₂) in human platelets. Also blocks glucose-induced insulin secretion in pancreatic islets. Possesses moderate leukotriene antagonist activity.

Biokémiai/fiziológiai hatások

Cell permeable: yes

Primary Target
A2PLA2

Product does not compete with ATP.

Reversible: no

Figyelmeztetés

Toxicity: Standard Handling (A)

Feloldás

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Egyéb megjegyzések

Liu, L., et al. 1999. J. Cell. Biochem.72, 103.
Simonsson, E., et al. 1998. Diabetes47, 1436.
Konrad, R.J., et al. 1992. Biochim. Biophys. Acta1135, 215.
Banga, H.S., et al. 1986. Proc. Natl. Acad. Sci. USA83, 9197.

Jogi információk

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Biztonsági adatok

• Tárolási osztály kódja: 11 - Combustible Solids
• WGK: WGK 1
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable